Multicomponent Strecker reaction under high pressure

Multicomponent Strecker reaction under high pressure
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DOI:
10.1002/hlca.200590136
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发表时间:
2005-01-01
影响因子:
1.8
通讯作者:
Jenner, G
Jenner, G
中科院分区:
化学4区
文献类型:
--
作者:
Matsumoto, K;Kim, JC;Jenner, G

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第一次,无催化,高压(0.6 GPa)与酮的反应已被证明是一个强大的方式来执行三组分Strecker合成的α-氨基腈在高产率。实现了两种类型的双重Strecker反应,但尝试进行三重Strecker反应是不成功的。
For the first time, uncatalyzed, high-pressure (0.6 GPa) reactions with ketones have proven to be a powerful way to perform the three-component Strecker synthesis of a-amino nitrites in high yields. Two types of double Strecker reactions were achieved, but attempts to perform triple Strecker reactions were unsuccessful.