CORRECTION OF RENAL HYPERTENSION IN THE RAT BY PROLONGED INFUSION OF ANGIOTENSIN INHIBITORS
CORRECTION OF RENAL HYPERTENSION IN THE RAT BY PROLONGED INFUSION OF ANGIOTENSIN INHIBITORS
复制标题
通过长期输注血管紧张素抑制剂纠正大鼠的肾高血压
DOI：
10.1016/s0140-6736(77)90366-x
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
B. Slack
中科院分区：
文献类型：
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作者：
A. Riegger;J. Millar;A. Lever;J. Morton;B. Slack
注射saralasin或转换酶抑制剂对双肾高血压大鼠的血压产生了小幅度的降低。长时间输注抑制剂可使血压逐渐降至正常。在正常动物中对照输注saralasin，在正常和高血压动物中对照输注葡萄糖，没有降低血压。血浆肾素浓度与血压早期下降有显著相关性，但与血压后期下降无相关性。血浆中的肾素和血管紧张素II的浓度密切相关，除了在大鼠接受转换酶抑制剂，当血管紧张素II相对减少。saralasin逐渐降低动脉压与尿钠排泄增加无关。
Injection of saralasin or converting-enzyme inhibitor produced a small variable reduction of blood-pressure in rats with two-kidney hypertension. Prolonged infusion of the inhibitors gradually reduced blood-pressure to normal. Control infusions of saralasin in normal animals and of dextrose in normal and hypertensive animals did not reduce blood-pressure. Plasma-renin concentration correlated significantly with the early but not with the later fall of blood-pressure. Plasma-concentrations of renin and angiotensin II were closely related except in rats receiving converting-enzyme inhibitor, when angiotensin II was relatively reduced. The gradual reduction of arterial pressure by saralasin was not associated with increased urinary sodium excretion.