Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients
Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients
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DOI：
10.1086/514298
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发表时间：
1999-02-01
影响因子：
6.4
通讯作者：
Muyembe-Tamfum, JJ
中科院分区：
文献类型：
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作者：
Mupapa, K;Massamba, M;Muyembe-Tamfum, JJ
1995年6月6日至22日，刚果民主共和国基奎特的8名符合基奎特埃博拉出血热病例定义的病人接受了5名康复期病人捐献的血液的输血。捐献的血液含有IgG EBO抗体，但不含EBO抗原。所有输血者输血前均检测到EBO抗原。8例输血患者的临床症状与流行期间观察到的其他EBO患者相似。所有患者均病情严重，伴有严重虚弱，4例出现出血症状，2例随着疾病进展而昏迷。只有1名输血患者（12.5%）死亡;这一数字明显低于基奎特EBO流行病的总病死率（80%）和其他EBO流行病的病死率。死亡率如此之低的原因尚待解释。输血的病人确实得到了比流行病初期更好的照顾。应制定计划，准备在新的EBO爆发期间对被动免疫治疗进行更彻底的评估。
Between 6 and 22 June 1995, 8 patients in Kikwit, Democratic Republic of the Congo, who met the case definition used in Kikwit for Ebola (EBO) hemorrhagic fever, were transfused with blood donated by 5 convalescent patients. The donated blood contained IgG EBO antibodies but no EBO antigen. EBO antigens were detected in all the transfusion recipients just before transfusion. The 8 transfused patients had clinical symptoms similar to those of other EBO patients seen during the epidemic. All were seriously ill with severe asthenia, 4 presented with hemorrhagic manifestations, and 2 became comatose as their disease progressed. Only 1 transfused patient (12.5%) died; this number is significantly lower than the overall case fatality rate (80%) for the EBO epidemic in Kikwit and than the rates for other EBO epidemics. The reason for this low fatality rate remains to be explained. The transfused patients did receive better care than those in the initial phase of the epidemic. Plans should be made to prepare for a more thorough evaluation of passive immune therapy during a new EBO outbreak.