Urinary crystal surface binding substances on calcium oxalate crystals
Urinary crystal surface binding substances on calcium oxalate crystals
复制标题
尿晶体表面结合草酸钙晶体上的物质
DOI：
10.1007/bf00297370
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发表时间：
2004
影响因子：
--
通讯作者：
T. Sonoda
中科院分区：
文献类型：
--
作者：
T. Koide;T. Yoshioka;S. Yamaguchi;S. Hosokawa;M. Utsunomiya;T. Sonoda
为了研究尿晶体表面结合物质（CSBS）的作用，我们采用草酸钙均质结晶的方法，从健康人尿液中提取天然存在的CSBS。事实证明，CSBS不是草酸钙晶体生长和聚集的促进剂，而是强抑制剂。综上所述，CSBS的抑制作用是通过掩盖晶体表面的生长位点和聚集位点来实现的。对于CSBS的特征，我们发现了10个左右的分子量峰，它们都含有多肽和糖类。研究结果表明，CSBS由多种糖蛋白和蛋白聚糖组成。
In order to study the effect of urinary crystal surface binding substances (CSBS), we extracted the naturally existing CSBS from urine from healthy individuals by conducting homogeneous crystallization of calcium oxalate. CSBS proved not to be promoters but rather strong inhibitors of calcium oxalate crystal growth and aggregation. It is suggested that CSBS exhibited their inhibitory effect by masking the growing sites and aggregating sites on the crystal surface. As for the characteristics of CSBS, we found around 10 peaks of molecular weight, and all of them contained both peptides and saccharides. The findings suggest that CSBS are composed of various kinds of glycoproteins and proteoglycans.