EXTENDED GENETIC-RECOMBINATION MAP FOR FOOT-AND-MOUTH-DISEASE VIRUS
EXTENDED GENETIC-RECOMBINATION MAP FOR FOOT-AND-MOUTH-DISEASE VIRUS
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DOI：
10.1099/0022-1317-35-3-555
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发表时间：
1977-01-01
影响因子：
3.8
通讯作者：
LAKE, JR
中科院分区：
文献类型：
--
作者：
MCCAHON, D;SLADE, WR;LAKE, JR
最初的口蹄疫病毒重组图谱，其中包括35个诱变剂诱导的ts突变体，扩展了详细和大小的映射进一步33 ts突变体（9诱变剂诱导和24自发）。最大重组频率从0.57%增加到3.27%的大小主要是由于使用了新的重组频率标准化技术，但由于新突变的定位，原始图谱距离增加了约30%。与原始图谱一样，在胍（gs）基因座附近有明显的突变集中，即，83%的突变体在邻近GS位点的图谱的第3个中具有突变。
The original foot-and-mouth disease virus recombination map, which included 35 mutagen-induced ts mutants, was extended in detail and size by the mapping of a further 33 ts mutants (9 mutagen-induced and 24 spontaneous). The size increase from 0.57 to 3.27% maximum recombination frequency was principally due to the use of a new standardization technique for recombination frequencies, but the original map distance was increased by about 30% due to the mapping of new mutations. As in the original map, there was a marked concentration of mutations near the guanidine (gs) locus, i.e., 83% of the mutants had mutations in the 3rd of the map adjacent to the gs locus.