Longitudinal association between toenail zinc levels and the incidence of diabetes among American young adults: The CARDIA Trace Element Study.
Longitudinal association between toenail zinc levels and the incidence of diabetes among American young adults: The CARDIA Trace Element Study.
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美国年轻人脚趾甲锌水平与糖尿病发病率之间的纵向关联：CARDIA 微量元素研究。
DOI：
10.1038/srep23155
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发表时间：
2016
影响因子：
4.6
通讯作者：
He,Ka
中科院分区：
文献类型：
--
作者：
Park,JongSuk;Xun,Pengcheng;Li,Jing;Morris,SteveJ;Jacobs,DavidR;Liu,Kiang;He,Ka
关于锌状况和糖尿病风险的一级预防的数据稀少且不一致。值得注意的是，以前的研究通过问卷调查或血清或头发中的锌状态来测量膳食锌摄入量。趾甲锌水平是相对长期暴露的可靠生物标志物。共有3，960名年龄在20-32岁之间的美国年轻人在1987年收集脚趾甲剪时基线时没有糖尿病，到2010年检查了糖尿病事件。用电感耦合等离子体质谱法测定趾甲锌水平。通过空腹或非空腹血糖水平、口服葡萄糖耐量试验、血红蛋白A1 C水平和/或抗糖尿病药物确定糖尿病事件。在23年的随访中，发生了418例糖尿病事件。在调整了年龄、性别、种族、研究中心、体重指数、教育、吸烟状况、饮酒、体力活动、糖尿病家族史、胰岛素抵抗的稳态模型评估以及其他饮食和非饮食潜在混杂因素后，比较趾甲锌水平最高和最低四分位数的糖尿病发病风险比为1.21（95% CI：0.90-1.63; P趋势= 0.20）。这项研究的结果并不支持锌状态与美国年轻人糖尿病发病率呈反向和纵向相关的假设。
Data on primary prevention of zinc status and diabetes risk are sparse and inconsistent. Of note, the previous studies measured either dietary zinc intake with questionnaire or zinc status in serum or hair. Toenail zinc levels are reliable biomarkers of a relatively long-term exposure. A total of 3,960 American young adults, aged 20–32 years, free of diabetes at baseline in 1987 when toenail clippings were collected, were examined for incident diabetes through 2010. Toenail zinc levels were measured with an inductively-coupled-plasma mass spectroscopy method. Incident diabetes cases were identified by fasting or non-fasting plasma glucose levels, oral glucose tolerance tests, hemoglobin A1C levels, and/or antidiabetic medications. During the 23-year follow-up, 418 incident diabetes occurred. After adjusted for age, sex, ethnicity, study center, body mass index, education, smoking status, alcohol consumption, physical activity, family history of diabetes, homeostasis model assessment of insulin resistance, and other dietary and non-dietary potential confounders, the hazard ratio of incident diabetes comparing the highest to the lowest quartile of toenail zinc levels was 1.21 (95% CI: 0.90–1.63;Ptrend= 0.20). Findings from this study do not support the hypothesis that zinc status is inversely and longitudinally associated with the incidence of diabetes in American young adults.