Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease
Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease
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DOI：
10.1097/00001756-200210070-00028
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发表时间：
2002-10-07
期刊：
影响因子：
1.7
通讯作者：
Masliah, E
中科院分区：
文献类型：
--
作者：
Ho, GJ;Hansen, LA;Masliah, E
本研究探讨了发病年龄对尸检证实的散发性路易体变异(LBV)和阿尔茨海默病(AD)患者认知功能、神经病理学和神经化学特征的影响。我们比较了28名早发性(小于或等于70岁)LBV受试者和28名匹配的晚发性(>；70岁)受试者。同样，我们在89名早发性AD患者和89名匹配的晚发性AD患者中检测了相同的特征。与晚发LBV和晚发AD患者相比，早发LBV和早发AD患者下降更快，神经炎斑块更多，新皮质胆碱能损失更大。综上所述，这些结果表明，对于LBV和AD来说，发病年龄较早可能预示着更具侵袭性的病程。
This study investigated the influence of age at onset on cognitive performance, neuropathological and neurochemical features in autopsy-confirmed sporadic Lewy body variant (LBV) and in Alzheimer's disease (AD). We compared 28 early-onset (less than or equal to 70 years) LBV subjects with 28 matched late-onset (> 70 years) subjects. Similarly, we examined the same features in 89 early onset AD and 89 matched late onset AD patients. Patients with early onset LBV and early onset AD declined more rapidly, had more neuritic plaques, and greater neocortical cholinergic loss compared to late onset LBV and late onset AD subjects. Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course.