HLA-DRB1*04 may predict the severity of disease in a group of Iranian COVID-19 patients.
HLA-DRB1*04 may predict the severity of disease in a group of Iranian COVID-19 patients.
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DOI：
10.1016/j.humimm.2021.07.004
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发表时间：
2021-10
期刊：
影响因子：
2.7
通讯作者：
Solgi G
中科院分区：
文献类型：
--
作者：
Ebrahimi S;Ghasemi-Basir HR;Majzoobi MM;Rasouli-Saravani A;Hajilooi M;Solgi G
人类白细胞抗原(人类白细胞抗原)基因具有极高的多样性，在SARS-COV-2感染的免疫应答中可能有个体差异的贡献。本研究旨在探讨伊朗新冠肺炎患者的HLAII类等位基因频率分布及其与疾病严重程度的关系。对144例新冠肺炎患者进行前瞻性病例对照研究，其中中度46例，重度54例，危重44例。采用聚合酶链式反应-单链构象多态(PCR-SSP)方法检测三组患者的等位基因家族-DRB1和-DQB1，并与153名民族匹配的健康对照组进行比较。与健康对照组比较，患者组的HLA-DRB1*15(OR=0.57，P=0.06)、DRB1*15~DQB1*05单倍型(P=0.04)和DRB1*15/DRB1*04(P=0.04)等位基因频率明显降低。中度新冠肺炎患者HLADRB1*04(P=0.03)、HLADRB1*10(P0.01)和DRB1*04/DRB1*11等位基因频率较高(P<0.01)。危重病患者组的HLADRB1*03等位基因频率显著高于对照组(P<0.01)。多因素Logistic回归分析显示，DRB1*04等位基因与重症和危重病的发生呈负相关(OR：0.289，P=0.005)。我们的结果提示某些HLAII类等位基因可能与新冠肺炎病的病情严重程度和临床特征有关。
Human leukocyte antigen (HLA) genes with extreme diversity can make a contribution for individual variations to the immune response against SARS-COV-2 infection. This study aimed to explore the distributions of HLA class II alleles frequencies and their relations with disease severity in a group of Iranian COVID-19 patients. This prospective and case-control study was conducted on 144 COVID-19 patients including 46 cases with moderate form, 54 cases with severe and 44 cases with critical disease. HLA-DRB1 and -DQB1 allele families were determined by PCR-SSP method and compared between three groups of the patients and in comparison to 153 ethnic-matched healthy controls. The patients group showed lower frequencies of HLA-DRB1*15 (OR = 0.57, P = 0.06), DRB1*15 ~ DQB1*05 haplotype (P = 0.04) and DRB1*15/DRB1*04 genotype (P = 0.04) in compare with healthy controls. Moderate COVID-19 patients had higher frequencies of HLA-DRB1*04 (P = 0.03), HLA-DRB1*10 (P = 0.05) and DRB1*04/DRB1*11 genotype (P = 0.01). Also, a higher significantly frequency of HLA-DRB1*03 allele group was observed in the critical patients versus controls (P = 0.01). Multiple logistic regression analysis revealed that the presence of DRB1*04 allele group was negatively associated with development of severe and critical disease (OR: 0.289, P = 0.005). Our results indicate a possible contribution of some HLA class II alleles in disease severity and clinical features of COVID-19 disease.
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影响因子：
5.6
作者：
Correale, Pierpaolo;Mutti, Luciano;Giordano, Antonio
通讯作者：
Giordano, Antonio
影响因子：
5.4
作者：
Chan, Che Man;Lau, Susanna K. P.;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
人白细胞抗原复合物以及其他免疫遗传和临床因素会影响对SARS-COV-2感染和疾病病程严重程度的敏感性或保护。撒丁岛的经历。
影响因子：
7.3
作者：
Littera R;Campagna M;Deidda S;Angioni G;Cipri S;Melis M;Firinu D;Santus S;Lai A;Porcella R;Lai S;Rassu S;Scioscia R;Meloni F;Schirru D;Cordeddu W;Kowalik MA;Serra M;Ragatzu P;Carta MG;Del Giacco S;Restivo A;Deidda S;Orrù S;Palimodde A;Perra R;Orrù G;Conti M;Balestrieri C;Serra G;Onali S;Marongiu F;Perra A;Chessa L
通讯作者：
Chessa L
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.4
作者：
Nguyen, Austin;David, Julianne K.;Thompson, Reid F.
通讯作者：
Thompson, Reid F.