Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study
Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study
复制标题
原发性开角型青光眼功能和解剖学半球间同位连接性降低：静息态 fMRI 和 DTI 联合研究
DOI：
10.1167/iovs.17-23291
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发表时间：
2018
影响因子：
4.4
通讯作者：
Xian Junfang
中科院分区：
文献类型：
--
作者：
Wang Qian;Chen Weiwei;Wang Huaizhou;Zhang Xun;Qu Xiaoxia;Ang Ying;Li Ting;Wang Ningli;Xian Junfang
目的：目的探讨原发性开角型青光眼（primary open-angle glaucoma，POAG）患者大脑半球间异常的同向功能连接是否伴随相应的解剖连接改变，并将连接改变与视网膜神经纤维层（retinal nerve fiber layer，RNFL）厚度和神经节细胞复合体（ganglion cell complex，GCC）厚度相关联。对16例POAG患者和19例健康对照者进行静息态功能磁共振成像（rs-fMRI）和弥散张量成像（DTI）检查。通过基于体素的全脑体素镜像同伦连接（VMHC）分析和VMHC引导的概率纤维束成像，得出了半球间同伦功能连接和基础解剖连接变化的指数。Pearson相关性分析被用来探讨半球间的同伦功能连接的变化和解剖连接的改变之间的相关性，和RNFL和GCC thickness.Results：减少VMHC值位于Brodmann区（BA）17，BA 18，和BA 19的双边同伦皮质区之间。在POAG患者中观察到BA 17和BA 18内连接双侧视觉皮层区域的解剖连接性降低。此外，平均RNFL厚度与BA 17的VMHC值降低呈正相关，（r= 0.572，P= 0.021）/BA18（r= 0.600，P= 0.014）/BA19经Pearson相关分析，两者之间的相关系数为r= 0.550，P= 0.027。结合纵裂同位功能连接和解剖连接的改变可能有助于阐明POAG患者纵裂同步性损伤的机制。VMHC值的降低与视网膜神经纤维层厚度的变化呈正相关，这加强了POAG使用一种新的功能性MRI特征影响视皮层的假设。
Purpose: To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness.Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls. Indices of interhemispheric homotopic functional connectivity and the underlying anatomic connectivity changes were derived with voxel-base whole-brain voxel-mirrored homotopic connectivity (VMHC) analyses and VMHC-guided probabilistic tractography. Pearson correlation analyses were used to explore the correlations between interhemispheric homotopic functional connectivity changes and anatomic connectivity alterations, and RNFL and GCC thickness.Results: Reduced VMHC values between bilateral homotopic cortical areas located in Brodmann area (BA) 17, BA18, and BA19. Decreased anatomic connectivity connecting bilateral visual cortical areas inside BA17 and BA18 were observed in POAG patients. Furthermore, positive correlations between average RNFL thickness and reduced VMHC values of BA17 (r= 0.572, P= 0.021)/BA18 (r= 0.600, P= 0.014)/BA19 (r= 0.550, P= 0.027) are found using Pearson correlation analyses.Conclusions: Combinations of interhemispheric homotopic functional connectivity and anatomic connectivity changes may help to elucidate the mechanism of interhemispheric synchronization injury in POAG patients. Reduced VMHC values positively correlate with glaucomatous changes of RNFL thickness, which strengthens the hypothesis that POAG affects the visual cortex using a novel functional MRI characteristic.