Use of lipid-lowering drugs and blood pressure control in patients with arterial hypertension.
Use of lipid-lowering drugs and blood pressure control in patients with arterial hypertension.
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DOI：
10.1111/j.1524-6175.2002.00499.x
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发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Ambrosioni, Ettore
中科院分区：
文献类型：
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作者：
Borghi, Claudio;Dormi, Ada;Ambrosioni, Ettore
大部分患者同时患有高血压和高胆固醇血症，这是心血管疾病的两个最重要的风险因素。他汀类药物是最广泛使用的治疗血脂异常的药物，并已报告与血压升高相互作用。在未经治疗的高血压患者和接受抗高血压药物（特别是血管紧张素转换酶抑制剂和钙通道阻滞剂）治疗的患者中，已报告了与使用这些药物相关的血压降低。在糖尿病患者中也观察到这种对血压控制的影响。引起这种抑制作用的机制似乎在很大程度上与他汀类药物对血浆胆固醇的影响无关，可能与药物与内皮功能或血管紧张素II受体的相互作用有关。他汀类药物改善血压控制的能力可能是改善心血管疾病预防的有用工具。
A large proportion of patients have both hypertension and hypercholesterolemia, two of the most important risk factors for cardiovascular diseases. Statins are the most widely used drugs for the treatment of plasma lipid abnormalities and have been reported to interact with elevated blood pressure. A reduction in blood pressure associated with the use of these agents has been reported in patients with untreated hypertension and in patients treated with antihypertensive drugs, particularly angiotensin-converting enzyme inhibitors and calcium channel blockers. This effect on blood pressure control has also been observed in diabetic patients. The mechanism responsible for the hypotensive effect seems to be largely independent of the effect of statins on plasma cholesterol, and probably is related to the interaction of the medications with endothelial function or angiotensin II receptors. The capacity of statins to improve blood pressure control may represent a useful tool for improvement in the prevention of cardiovascular diseases.