Investigation of the oral infections and manifestations seen in patients with advanced cancer.
Investigation of the oral infections and manifestations seen in patients with advanced cancer.
复制标题
晚期癌症患者口腔感染及表现的调查
DOI：
10.12669/pjms.295.3493
复制
发表时间：
2013-09
影响因子：
2.2
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Xu L;Zhang H;Liu J;Chen X
目的：本研究采用前瞻性、观察性研究方法，调查晚期恶性肿瘤患者口腔感染的流行病学特征，并探讨治疗策略和危险因素对口腔感染发生率的影响。方法：选择晚期恶性肿瘤患者作为研究对象。比较不同恶性肿瘤组及不同治疗方法口腔感染的发生率，明确口腔感染的诊断。此外，亦会记录年龄、性别、卧床时间、营养状况、吸烟习惯及口腔修复情况等人口统计资料。结果如下：口腔感染的发生率为46%（391/850），口腔颌面部恶性肿瘤组为67%（24/850），其次为血液系统恶性肿瘤组（58.6%）和其他恶性肿瘤组（43.3%~ 35.3%）。口腔念珠菌病、口腔单纯疱疹、口腔黏膜炎是患者常见的感染性疾病。与姑息治疗和手术相比，化疗和放疗，特别是联合放疗和化疗，导致更多的口腔感染。营养不良和口腔修复体被确定为与口腔感染相关的独立危险因素。结论：口腔感染在晚期癌症患者中普遍存在，并与治疗方法和危险因素有关。对晚期恶性肿瘤患者应加强口腔保健。
Objective: A prospective, observational study was undertaken to investigate the epidemiology of oral infection among the patients with advanced malignancies, and to investigate the effects of therapy strategies and risk factors on the incidence of oral infection. Methods: The patients with advanced malignancies were enrolled into the study. The incidence of oral infection with different malignant tumor groups or different treatment methods and the diagnoses of oral infection were confirmed. Demographic data on age, gender, bed rest time, nutritional status, smoking habit and the presence of oral prosthesis were also recorded. Results: Oral infection was prevalent in 46% (391/850) of all cancer patients, with the highest rate in oral and maxillofacial cancer group (67%), followed by Hematological malignancy group (58.6%) and other groups (ranging from 43.3% to 35.3%). Oral candidiasis, oral herpes simplex, and oral mucositis were the popular infectious diseases in the patients. Chemotherapy and radiotherapy, especially combined radio- and chemotherapy, resulted in more oral infections compared with palliative care and surgery. Poor nutritional status and oral prosthesis were identified as independent risk factors associated with oral infection. Conclusion: Oral infection is prevalent among advanced cancer patients and associated with therapy methods and risk factors. More oral health care should be carried out for the patients with advanced malignant tumor.