Associations of autoimmune bullous diseases and autoantibodies against epidermal autoantigens in patients with inflammatory myopathy
Associations of autoimmune bullous diseases and autoantibodies against epidermal autoantigens in patients with inflammatory myopathy
复制标题
炎症性肌病患者自身免疫性大疱性疾病与表皮自身抗原自身抗体的相关性
DOI：
10.1093/mr/roac159
复制
发表时间：
2022
期刊：
影响因子：
2.2
通讯作者：
Fujimoto N
中科院分区：
文献类型：
--
作者：
Kokubu H;Takahashi T;Tateishi C;Hashimoto T;Tsuruta D;Fujimoto N
Autoimmune bullous diseases (AIBDs) have been reported to occur in patients with idiopathic inflammatory myopathies (IIMs). We previously reported a case of pemphigus foliaceus (PF) associated with anti-NXP2 autoantibody (Ab)-positive dermatomyositis (DM)[1]. Regarding the association of AIBDs and IIMs, almost all cases of IIMs with AIBDs including our case were not polymyositis (PM) but DM who had epidermal damage by eruptions [1]. We speculated that both immunological abnormality of autoimmune diseases and epidermal damage due to eruption of DM could induce Abs against the basement membrane zone of the epidermis. In this study, we first performed a survey of literature on various AIBDs associated with IIMs. Including our case, we collected 19 cases (6 males and 13 females, 53.7±19.2 years old) from 1982 to 2022 (Table 1)[1–5]. This survey revealed that 14 (73.7%) cases of AIBDs developed after the onset of IIM. Seventeen (89.5%) cases had DM. Notably, all five cases that developed both AIBDs and IIMs within 1 year were subepidermal AIBDs [bullous pemphigoid, mucous membrane pemphigoid, linear immunoglobulin G (IgG) disease, and bullous lupus erythematosus (LE)]. Epidermal damage due to eruption of DM might preferentially occur in subepidermal AIBDs than in intraepidermal AIBDs (pemphigus vulgaris, PF, and paraneoplastic pemphigus). However, the mechanism of production of Abs against epidermal autoantigens in IIM patients is still unknown. In addition, there is a possibility that IIM patients may have preclinical Abs to epidermal autoantigens before the development of AIBDs. Therefore, we next investigated whether IIM patients have pathogenic or non-pathogenic Abs against the epidermis.We collected sera from 24 DM and 9 PM patients before the treatment in the Department of Dermatology of Shiga University of Medical Science. No cutaneous lesions suspicious of AIBDs were observed at the time of serum collection, except for the previously reported case that developed PF after the
