Networking in the nucleus: a spotlight on LEM-domain proteins.
Networking in the nucleus: a spotlight on LEM-domain proteins.
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DOI：
10.1016/j.ceb.2015.03.005
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发表时间：
2015-06
影响因子：
7.5
通讯作者：
Geyer PK
中科院分区：
文献类型：
--
作者：
Barton LJ;Soshnev AA;Geyer PK
居住在核膜内和下面的核层的蛋白质形成一个网络，调节核功能。本文综述了一个携带lap2 -emerin- man1结构域（LEM-D）的核层蛋白家族。LEM-D蛋白具有结合核层蛋白和系住核外周抑制染色质的能力。研究结果强调了这个家族的重要性，即单个LEM-D蛋白的缺失会导致进行性、组织限制性疾病，即椎板病。LEM-D蛋白的多种功能与独特和重叠的伙伴相互作用有关，包括信号转导效应物、转录因子和建筑蛋白。最近的研究表明，LEM-D蛋白在核层内形成枢纽，整合对组织稳态和维持祖细胞群很重要的外部信号。
Proteins resident in the inner nuclear membrane and underlying nuclear lamina form a network that regulates nuclear functions. This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D proteins share an ability to bind lamins and tether repressive chromatin at the nuclear periphery. The importance of this family is underscored by findings that loss of individual LEM-D proteins causes progressive, tissue-restricted diseases, known as laminopathies. Diverse functions of LEM-D proteins are linked to interactions with unique and overlapping partners including signal transduction effectors, transcription factors and architectural proteins. Recent investigations suggest that LEM-D proteins form hubs within the nuclear lamina that integrate external signals important for tissue homeostasis and maintenance of progenitor cell populations.