Sensory nerves and urinary bladder function: effects of diabetes, capsaicin and acrylamide treatment.
Sensory nerves and urinary bladder function: effects of diabetes, capsaicin and acrylamide treatment.
复制标题
感觉神经和膀胱功能：糖尿病、辣椒素和丙烯酰胺治疗的影响。
DOI：
10.1016/0306-3623(89)90056-6
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Wallace,LJ
中科院分区：
文献类型：
--
作者：
Kudlacz,EM;Gerald,MC;Wallace,LJ
1.比较了丙烯酰胺、辣椒素和糖尿病对大鼠膀胱压力反应的拟议神经毒性作用，这些反应是通过将缓冲液注入器官（扩张）引起的。2.辣椒素或丙烯酰胺治疗完全消除膀胱压力反应。3.在相当于糖尿病模型的利尿4周后，与对照组相比，压力反应显著降低。这种反应在L-DOPA后大大增加，L-DOPA增强了排尿反射。4.链脲佐菌素诱导的糖尿病4周后，与对照组相比，压力反应略有减弱，并且与用L-DOPA治疗的利尿剂组的反应最相似。
1. A comparison was made of the proposed neurotoxic effects of acrylamide, capsaicin, and diabetes on rat urinary bladder pressure responses elicited by infusion of buffer into the organ (distension). 2. Treatment with capsaicin or acrylamide completely abolished the bladder pressure responses. 3. After 4 weeks of diuresis equivalent to that of the diabetic model, the pressure response was markedly diminished compared to control. This response was greatly increased following L-DOPA, which augments the micturition reflex. 4. After 4 weeks of streptozoticin-induced diabetes, the pressure response was slightly diminished compared to control and most closely resembled the response from the diuretic group treated with L-DOPA.