Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature
Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature
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DOI：
10.1034/j.1600-0560.2002.290112.x
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发表时间：
2002-01-01
影响因子：
1.7
通讯作者：
Schmitt, FC
中科院分区：
文献类型：
--
作者：
Reis, JS;Milanezi, F;Schmitt, FC
背景资料：梭形细胞/多形性脂肪瘤（SC/PL）是一种良性脂肪组织肿瘤，通常影响中年男性患者的肩部，背部和颈部区域的皮下组织。组织学上，其特征在于存在排列成短束的原始CD 34阳性梭形细胞、奇异的小花样多核巨细胞、成熟脂肪细胞和少量成脂细胞。最近，空气皮内亚组已被描述，它主要影响女性患者，并提出了一个更广泛的解剖学分布时相比，经典的变异SC/PL。方法：我们报告的情况下，皮内SC/PL影响大阴唇的56岁女性患者。结果：组织学检查显示了典型的组织学特征，但病变边界不清，浸润性，以及真皮神经的参与。免疫组化分析，根据链霉亲和素-生物素-过氧化物酶技术显示免疫反应CD 34和波形蛋白的梭形细胞，以及S100蛋白和波形蛋白的脂肪细胞。结论：据我们所知，这是第一例皮内SC/PL影响外阴区域。我们必须小心不要将此罕见肿瘤误诊为高分化脂肪肉瘤、细胞性血管纤维瘤、孤立性纤维瘤及皮肤神经纤维瘤。
Background: Spindle cell/pleomorphic lipoma (SC/PL) is a benign adipose tissue tumor that usually affects the subcutaneous tissues of shoulders, backs, and neck region of middle-aged male patients. Histologically, it is characterized by the presence of primitive CD34-positivc spindle cells arranged in short fascicles, bizarre floret-like multinucleated giant cells, mature adipocytes, and a small number of lipoblasts. Recently, air intradermal subset has been described, which mainly affects female patients and presents a wider antomical distribution when compared to the classical variant of SC/PL.Methods: We report a case, of intradermal SC/PL affecting the labium majus of a 56-year-old female patient.Results: The histological examination disclosed the typical histological features, however the lesion showed poorly demarcated and infiltrative borders, as well as involvement of dermal nerves. The immunohistochemical analysis according to streptovidin-biotin-peroxidase technique showed immunoreactivity for CD34 and vimentin in the spindle cells, as well as S100 protein and vimentin in the adipocytic cells.Conclusions: To the best of our knowledge, this is the first case of intradermal SC/PL affecting the vulvar region. Care must be taken not to misdiagnosis this rare tumor as well-differentiated liposarcoma, cellular angiofibroma, solitary fibrous tumor, and cutaneous neurofibroma.