Associations Between Vitamins C and D Intake and Cartilage Composition and Knee Joint Morphology Over 4 Years: Data From the Osteoarthritis Initiative
Associations Between Vitamins C and D Intake and Cartilage Composition and Knee Joint Morphology Over 4 Years: Data From the Osteoarthritis Initiative
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DOI：
10.1002/acr.24021
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发表时间：
2020-09-01
影响因子：
4.7
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
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作者：
Joseph, Gabby B.;McCulloch, Charles E.;Link, Thomas M.
目的使用骨关节炎倡议（OAI）队列的数据，确定维生素C和D摄入量与软骨成分（T2）和关节结构（软骨，半月板和骨髓）的磁共振成像（MRI）测量的横截面和纵向相关性。方法从OAI数据库中选择1,785例右膝Kellgren/Lawrence膝关节影像学评分0-3级的受试者。使用Block Brief 2000食物频率问卷在基线时评估维生素C和维生素D摄入量（饮食、补充剂和总量）。MRI分析方案包括基线和4年时的3 T软骨T2定量和半定量关节形态分级（全器官磁共振成像评分[蠕虫]）。线性回归用于评估标准化基线维生素摄入量与基线WORM评分和标准化软骨T2值之间的相关性。结果维生素C摄入量越高，平均软骨T2值、胫骨内侧T2值和胫骨内侧WORMS评分越低（标准化系数范围为-0.07 ~-0.05，P < 0.05）。高维生素D摄入量与较低的软骨WORMSsum评分和股骨内侧WORMSsum评分相关（标准化系数范围为-0.24 ~-0.09，P < 0.05）。坚持每周至少一次补充400 IU维生素D超过4年与软骨、半月板和骨髓异常的恶化显著减少相关（比值比范围0.40- 0.56，P < 0.05）。结论补充维生素D超过4年与膝关节异常的进展明显减少相关。鉴于这项研究的观察性质，未来的纵向随机对照试验补充维生素D是必要的。
Objective To determine the cross-sectional and longitudinal associations of vitamin C and D intake with magnetic resonance imaging (MRI) measures of cartilage composition (T2) and joint structure (cartilage, meniscus, and bone marrow) using data from the Osteoarthritis Initiative (OAI) cohort. Methods A total of 1,785 subjects with radiographic Kellgren/Lawrence knee grades 0-3 in the right knee were selected from theOAIdatabase. Vitamins C and vitamin D intake (diet, supplements, and total) were assessed using the Block Brief 2000 Food Frequency Questionnaire at baseline. TheMRIanalysis protocol included 3T cartilage T2 quantification and semiquantitative joint morphology gradings (Whole-Organ Magnetic Resonance Imaging Score [WORMS]) at baseline and 4 years. Linear regression was used to assess the association between standardized baseline vitamin intake and both baselineWORMSscores and standardized cartilage T2 values. Results Higher vitamin C intake was associated with lower average cartilage T2 values, medial tibia T2 values, and medial tibiaWORMSscores (standardized coefficient range -0.07 to -0.05,P< 0.05). Higher vitamin D intake was associated with a lower cartilageWORMSsum score and medial femurWORMSscore (standardized coefficient range -0.24 to -0.09,P< 0.05). Consistent use of vitamin D supplements of 400IUat least once a week over 4 years was associated with significantly less worsening of cartilage, meniscus, and bone marrow abnormalities (odds ratio range 0.40-0.56,P< 0.05). Conclusion Supplementation with vitamin D over 4 years was associated with significantly less progression of knee joint abnormalities. Given the observational nature of this study, future longitudinal randomized controlled trials of vitamin D supplementation are warranted.