Cascade radical carbonylations leading to 3-substituted cyclohexanones
Cascade radical carbonylations leading to 3-substituted cyclohexanones
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DOI：
10.1055/s-2006-949643
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发表时间：
2006-09
期刊：
影响因子：
2
通讯作者：
Yoshitaka Uenoyama;T. Fukuyama;I. Ryu
中科院分区：
文献类型：
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作者：
Yoshitaka Uenoyama;T. Fukuyama;I. Ryu
研究了锡自由基介导的[5+1]-成环方法，产生3-取代的环己酮。通过烯丙基锡介导的三组分和四组分级联反应以良好的产率合成了在 3 位具有季中心的环己酮，这些反应涉及 (i) 自由基羰基化、(ii) 6-内环化和 (iii) 烯烃加成。
Tin radical mediated [5+1]-annulation methods leading to 3-substituted cyclohexanones were investigated. Cyclohexanones having a quaternary center at the 3-position were synthesized in good yields by allyltin-mediated three- and four-component cascade reactions that involve (i) radical carbonylation, (ii) 6-endo cyclization, and (iii) alkene addition.