Slow-release local chemotherapeutic regimen for maxillary sinus cancer.
Slow-release local chemotherapeutic regimen for maxillary sinus cancer.
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上颌窦癌的缓释局部化疗方案。
DOI：
10.1016/s0385-8146(86)80044-x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Tomita
中科院分区：
文献类型：
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作者：
A. Kida;S. Kawamura;T. Furusaka;Y. Yokode;H. Hasegawa;M. Aoyagi;K. Kikuchi;H. Tomita
含有博来霉素（BLM）的硅胶泡沫植入肿瘤切除术后的腔内，似乎通过缓慢释放这种抑癌剂，以微观量对抗残留在切除部位的任何肿瘤细胞。硅酮泡沫在发泡和硬化时精确地根据创面的形状模制，在材料和创面之间不留任何空间。因此，释放的抑癌剂可以作用于伤口的整个表面，并且植入也具有止血效果。通过硅胶泡沫的缓释特性，可以长时间保持药剂的高组织浓度。手术的全身副作用似乎可以忽略不计。我们的32名患者中有11名（33.4%）观察到癌症局部复发。3年生存率：T21期1例（50%），T3期11例（68.7%），T4期4例（66.6%）。
Silicone foam containing bleomycin (BLM) and implanted in the cavity resulting from the resection of a tumor seemed to act against any tumor cells remaining in the resection site in microscopic amounts by slowly releasing this carcinostatic agent. The silicone foam is molded in precise accordance with the shape of the wound surface as it foams and hardens, leaving no space between the material and the wound surface. The carcinostatic agent released can, therefore, act on the entire surface of the wound, and the implantation also has a hemostatic effect. High tissue concentrations of the agent can be maintained for a long time by the slow-release properties of the silicone foam. Systemic side effects of the procedure seem to be negligible. Local recurrence of cancer was observed in 11 (33.4 %) of our 32 patients. Three-year survival was seen in 1 (50 %) of the 2 patients with T21esions, 11 (68.7 %) of the 16 with T3 lesions and 4 (66.6 %) of the 6 with T4 lesions.