The LNK Gene Family: At the Crossroad between Light Signaling and the Circadian Clock
The LNK Gene Family: At the Crossroad between Light Signaling and the Circadian Clock
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DOI：
10.3390/genes10010002
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发表时间：
2019-01-01
期刊：
影响因子：
3.5
通讯作者：
Javier Yanovsky, Marcelo
中科院分区：
文献类型：
--
作者：
Jose de Leone, Maria;Esteban Hernando, Carlos;Javier Yanovsky, Marcelo
光信号通路与生物钟相互作用，帮助生物体将生理和发育过程与周期性环境周期同步。负责时钟重置的植物光感受器已被表征，但将光感受器与时钟联系起来的信号成分仍有待确定。NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED（LNK）基因家族成员在拟南芥中起着关键作用，将基因表达的光调控与日常和季节节律的控制联系起来。特别是，LNK 1和LNK 2被证明控制昼夜节律，光形态发生反应，和光周期依赖的开花时间。在这里，我们分析了在这些过程中的拟南芥中的LNK家族的四个成员的作用。我们发现，在lnk 1，lnk 2突变体背景下，密切相关的LNK 3和LNK 4的耗尽会影响昼夜节律，但不会影响其他时钟调节过程，如开花时间和幼苗光形态建成。然而，在所有LNK基因缺陷的植物（lnkQ四重突变体）显示发育改变，导致增加莲座大小，生物量，并增强向光性反应。我们的工作表明，LNK家族成员具有独特的和部分重叠的功能，并且是协调光调节发育过程的重要环节。
Light signaling pathways interact with the circadian clock to help organisms synchronize physiological and developmental processes to periodic environmental cycles. The plant photoreceptors responsible for clock resetting have been characterized, but signaling components that link the photoreceptors to the clock remain to be identified. Members of the family of NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED (LNK) genes play key roles linking light regulation of gene expression to the control of daily and seasonal rhythms in Arabidopsis thaliana. Particularly, LNK1 and LNK2 were shown to control circadian rhythms, photomorphogenic responses, and photoperiod-dependent flowering time. Here we analyze the role of the four members of the LNK family in Arabidopsis in these processes. We found that depletion of the closely related LNK3 and LNK4 in a lnk1;lnk2 mutant background affects circadian rhythms, but not other clock-regulated processes such as flowering time and seedling photomorphogenesis. Nevertheless, plants defective in all LNK genes (lnkQ quadruple mutants) display developmental alterations that lead to increased rosette size, biomass, and enhanced phototropic responses. Our work indicates that members of the LNK family have both distinctive and partially overlapping functions, and are an essential link to orchestrate light-regulated developmental processes.