Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data
Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data
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DOI：
10.1016/j.medmal.2014.08.005
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发表时间：
2014-09-01
影响因子：
5
通讯作者：
Glele, L. S. Aho
中科院分区：
文献类型：
--
作者：
Lefebvre, A.;Fiet, C.;Glele, L. S. Aho
Objective. - 我们的目标是估计扎伊尔、苏丹和本迪布焦埃博拉物种的病死率，这些物种有时会导致致命的出血热。- 我们对世界卫生组织关于这些物种引起的感染爆发的数据进行了荟萃分析。- 研究了20次爆发，包括目前的一次。估计病死率为65.4%（置信区间95% [54.6%; 75.5%]），且在不同暴发中有所不同。确定了种属效应，扎伊尔种属的病死率高于苏丹种属和本迪布焦种属。扎伊尔种的病死率随着时间的推移呈下降趋势。- 与这3个物种相关的病死率很高。观察到很大的变异性。这可以部分解释为物种效应和扎伊尔物种病死率随时间的下降。(C)2014年Elsevier Masson SAS。All rights reserved.
Objective. -Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers.Methods. -We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species.Results. -Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time.Conclusion. -The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time. (C) 2014 Elsevier Masson SAS. All rights reserved.