SPIROCHETAL ANTIGENS AND LYMPHOID-CELL SURFACE-MARKERS IN LYME SYNOVITIS - COMPARISON WITH RHEUMATOID SYNOVIUM AND TONSILLAR LYMPHOID-TISSUE
SPIROCHETAL ANTIGENS AND LYMPHOID-CELL SURFACE-MARKERS IN LYME SYNOVITIS - COMPARISON WITH RHEUMATOID SYNOVIUM AND TONSILLAR LYMPHOID-TISSUE
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DOI：
10.1002/art.1780310405
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发表时间：
1988-04-01
影响因子：
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通讯作者：
BUTCHER, EC
中科院分区：
文献类型：
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作者：
STEERE, AC;DURAY, PH;BUTCHER, EC
使用单克隆抗体螺旋体抗原和淋巴细胞表面标志物，我们检查了12例莱姆病患者的滑膜病变，并与类风湿性滑膜和扁桃体淋巴组织进行了比较。莱姆病患者和类风湿性关节炎患者的滑膜病变相似，通常由正常组织淋巴组织中发现的成分组成。在这两种疾病中，T细胞（主要是辅助/诱导亚群）弥漫分布在滑膜下衬里区域，通常伴有紧密混合的T细胞和B细胞的结节聚集体。IgD-承载B细胞分散在聚集体中，有时存在少数滤泡树突状细胞和活化的生发中心B细胞。在病灶外可见大量浆细胞、高内皮微静脉、散在的巨噬细胞和少量树突状巨噬细胞，HLA-DR和DQ在整个病灶内表达强烈。在12例莱姆关节炎患者中的6例中，淋巴细胞浸润区域的血管内和血管周围可见少量螺旋体和球状抗原沉积，但类风湿关节炎患者中无一例。因此，在莱姆关节炎中，少量螺旋体可能是慢性滑膜炎的抗原刺激物。
Using monoclonal antibodies to spirochetal antigens and lymphoid cell surface markers, we examined the synovial lesions of 12 patients with Lyme disease, and compared them with rheumatoid synovium and tonsillar lymphoid tissue. The synovial lesions of Lyme disease patients and rheumatoid arthritis patients were similar and often consisted of the elements found in normal organized lymphoid tissue. In both diseases, T cells, predominantly of the helper/inducer subset, were distributed diffusely in subsynovial lining areas, often with nodular aggregates of tightly intermixed T and B cells. IgD-bearing B cells were scattered within the aggregates, and a few follicular dendritic cells and activated germinal center B cells were sometimes present. Outside the aggresates, many plasma cells, high endothelial venules, scattered macrophages, and a few dendritic macrophages were found. HLA-DR and DQ expression was intense throughout the lesions. In 6 of the 12 patients with Lyme arthritis, but in none of those with rheumatoid arthritis, a few spirochetes and globular antigen deposits were seen in and around blood vessels in areas of lymphocytic infiltration. Thus, in Lyme arthritis, a small number of spirochetes are probably the antigenic stimulus for chronic synovial inflammation.