Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.
Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.
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DOI：
10.1523/jneurosci.2612-10.2010
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发表时间：
2010-11-10
期刊：
影响因子：
--
通讯作者：
Milham MP
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文献类型：
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作者：
Zuo XN;Kelly C;Di Martino A;Mennes M;Margulies DS;Bangaru S;Grzadzinski R;Evans AC;Zang YF;Castellanos FX;Milham MP
功能同伦，即几何上对应的半球间(即同伦)区域之间自发活动的高度同步性，是大脑内在功能结构的一个基本特征。然而，尽管它的突出，人类大脑的同源静息态功能连接(RSFC)的寿命发育在功能磁共振成像研究中很少被直接研究。在这里，我们系统地研究了214名年龄从7岁到85岁的健康个体的同位RSFC的年龄相关变化。我们观察到同位的RSFC的显著年龄相关变化，具有不同复杂程度的地区性特定发育轨迹。随着年龄的增长，感觉运动区的同位RSFC趋于增加，而高阶加工区的连通性降低(即分离增加)。更复杂的成熟曲线也被检测到，岛回和舌回等区域呈二次轨迹，额上回和壳核呈立方轨迹。在背外侧前额叶皮质(BA9和46)和杏仁核中发现了功能同伦发育轨迹的性别差异。有证据表明，同源RSFC在整个生命周期中具有强大的发育效应，这应该有助于推动对神经退行性疾病和精神障碍中潜在的功能同伦的生理机制的研究。
Functional homotopy, the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric (i.e., homotopic) regions, is a fundamental characteristic of the brain’s intrinsic functional architecture. Yet, despite its prominence, the lifespan development of human brain’s homotopic resting-state functional connectivity (RSFC) is rarely directly examined in functional magnetic resonance imaging studies. Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy individuals ranging in age from 7 to 85. We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity. Sensorimotor regions tended to show increasing homotopic RSFC whereas higher order processing regions showed decreasing connectivity (i.e., increasing segregation) with age. More complex maturational curves were also detected, with regions such as the insula and lingual gyrus exhibiting quadratic trajectories, and the superior frontal gyrus and putamen exhibiting cubic trajectories. Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex (BA 9 and 46) and amygdala. Evidence of robust developmental effects in homotopic RSFC across the lifespan should serve to motivate studies of the physiological mechanisms underlying functional homotopy in neurodegenerative and psychiatric disorders.