EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
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DOI：
10.1136/ard.2003.011742
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发表时间：
2003-12-01
影响因子：
27.4
通讯作者：
Dougados, M
中科院分区：
文献类型：
--
作者：
Jordan, KM;Arden, NK;Dougados, M
目的：更新EULAR建议的管理膝关节骨关节炎（OA）的循证医学和专家意见approximates.Methods：文献检索和指南仅限于治疗膝关节骨性关节炎有关的临床和/或放射性骨关节炎的膝关节的任何隔室。排除膝关节和其他类型OA联合治疗的文献。使用主题词和关键词的组合检索Medline和Embase。在1999年1月至2002年2月期间对先前研究的治疗进行了研究，在1966年至2002年2月期间对先前未研究的治疗进行了研究。记录每种治疗的证据水平。质量分数确定为每篇论文，效果大小比较治疗与安慰剂进行计算，在可能的情况下，并确定每个治疗model.Results：497个新的出版物被确定的搜索的毒性配置文件。其中，103项为干预试验，并纳入总体分析，确定了33种治疗方式。在初始分析中，先前识别的不完全是膝关节OA的出版物被拒绝。共纳入545篇出版物。根据文献检索结果和专家意见，采用五阶段德尔菲技术设计了10种治疗膝关节OA的建议。根据专家意见，进一步确定了一组10个项目的五个阶段的德尔菲技术作为重要的未来research.Conclusion：更新后的建议，支持一些以前的命题发表在2000年，但也包括修改后的声明和新的命题。尽管存在大量膝关节OA的治疗选择，但EULAR建议的循证格式继续确定目前尚未回答的关键临床问题。
Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach.Methods: The literature search and guidelines were restricted to treatments for knee OA pertaining to clinical and/or radiological OA of any compartment of the knee. Papers for combined treatment of knee and other types of OA were excluded. Medline and Embase were searched using a combination of subject headings and key words. Searches for those treatments previously investigated were conducted for January 1999 to February 2002 and for those treatments not previously investigated for 1966 to February 2002. The level of evidence found for each treatment was documented. Quality scores were determined for each paper, an effect size comparing the treatment with placebo was calculated, where possible, and a toxicity profile was determined for each treatment modality.Results: 497 new publications were identified by the search. Of these, 103 were intervention trials and included in the overall analysis, and 33 treatment modalities were identified. Previously identified publications which were not exclusively knee OA in the initial analysis were rejected. In total, 545 publications were included. Based on the results of the literature search and expert opinion, 10 recommendations for the treatment of knee OA were devised using a five stage Delphi technique. Based on expert opinion, a further set of 10 items was identified by a five stage Delphi technique as important for future research.Conclusion: The updated recommendations support some of the previous propositions published in 2000 but also include modified statements and new propositions. Although a large number of treatment options for knee OA exist, the evidence based format of the EULAR Recommendations continues to identify key clinical questions that currently are unanswered.