The autoantigenic response to rabbit cytochrome c.
The autoantigenic response to rabbit cytochrome c.
复制标题
对兔细胞色素c的自身抗原反应。
DOI：
10.1002/eji.1830190215
复制
发表时间：
1989
影响因子：
5.4
通讯作者：
Paterson,Y
中科院分区：
文献类型：
--
作者：
Cooper,HM;Klinman,NR;Paterson,Y
在本报告中，我们描述了用天然单体或聚合形式的兔细胞色素（cytc）免疫的兔子中对兔细胞色素（cytc）的自身抗体反应的产生和表征。对该反应的精细特异性分析表明，大部分反应是针对分子的进化保守的氨基末端区域。通过固相测定评估了自身抗体与兔细胞抗体相互作用的相对亲和力，发现其低于兔抗马细胞抗体群体观察到的亲和力。这些发现与低亲和力自身反应性 B 细胞可能逃避耐受诱导的预测一致。
In this report we describe the production and characterization of autoantibody responses to rabbit cytochromec(cytc) in rabbits immunized with either the native monomeric or polymerized form of rabbit cytc.Fine‐specificity analyses of the response indicated that the majority of the response was to the evolutionarily conserved ammo‐terminal region of the molecule. The relative affinity of the autoantibody interaction with rabbit cytcwas assessed by a solid‐phase assay and was found to be lower than that observed for rabbit anti‐horse cytcantibody populations. These findings are consistent with the prediction that low‐affinity self‐reactive B cells may escape tolerance induction.