Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance
Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance
复制标题
Yes相关蛋白（YAP）在癌症进展和抗癌治疗耐药中的作用
DOI：
10.26599/bsa.2022.9050008
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发表时间：
2022-03
影响因子：
--
通讯作者：
Xiuping Zhou
中科院分区：
文献类型：
--
作者：
Yu Zhang;Xiang Wang;Xiuping Zhou
Hippo通路是一种高度保守的激酶级联，调节细胞增殖、凋亡、器官大小和组织稳态。据报道，该途径的失调在各种人类癌症的进展中起重要作用。是相关蛋白（雅普）是Hippo通路的核心效应子，被认为是癌症治疗和患者预后的标志物。此外，研究表明，雅普参与促进抗癌药物耐药性。本文综述了雅普在肿瘤进展、耐药中的作用以及以YAP为靶点的药物研究进展。深入了解雅普在肿瘤进展中的作用，将有助于深入了解肿瘤耐药的机制。通过新的联合治疗可能会改善预后。
The Hippo pathway, a highly conserved kinase cascade, regulates cell proliferation, apoptosis, organ size, and tissue homeostasis. Dysregulation of this pathway reportedly plays an important role in the progression of various human cancers. Yes-association protein (YAP), the Hippo pathway’s core effector, is considered a marker for cancer therapy and patient prognosis. In addition, studies have indicated that YAP is involved in promoting anticancer drug resistance. This review summarizes current knowledge on YAP’s role in cancer progression, anticancer drug resistance, and advances in the development of YAP-targeting drugs. A thorough understanding of the complex interactions among molecular, cellular, and environmental factors concerning YAP function in cancer progression may provide new insight into the underlying mechanism of anticancer drug resistance. It might lead to improved prognosis through novel combined therapies.
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