Sleep in patients with schizophrenia.
Sleep in patients with schizophrenia.
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DOI：
10.1007/s40675-015-0010-3
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发表时间：
2015-06-01
影响因子：
1.8
通讯作者：
Ferrarelli F
中科院分区：
文献类型：
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作者：
Ferrarelli F
许多电生理学和神经影像学研究报道了精神分裂症患者在清醒时的神经生理和认知缺陷。然而，这些发现在不同的患者群体中并不一致，因此使潜在神经元缺陷的识别复杂化。睡眠可以最大限度地减少可能的与觉醒有关的混乱，包括动机减少和活动症状的存在。此外，两种主要的睡眠节律，慢波和纺锤波，反映了皮质丘脑回路的内在活动，并与清醒期间发生的认知活动，包括学习和记忆有关。在这篇综述中，我将介绍精神分裂症中最相关的睡眠研究结果，特别强调最近几项研究，这些研究一直报告精神分裂症患者的睡眠纺锤体缺陷。然后，我将详细说明这些发现如何有助于更好地了解精神分裂症的神经生物学，以及开发新的药理学和非药理学干预措施，以改善精神分裂症患者的症状和认知障碍。
Numerous electrophysiological and neuroimaging studies have reported neurophysiological and cognitive deficits in schizophrenia patients during wakefulness. However, these findings have been inconsistently replicated across different groups of patients, thus complicating the identification of underlying neuronal defects. Sleep minimizes possible waking-related confounds, including decreased motivation and presence of active symptoms. Additionally, the two main sleep rhythms, slow waves and spindles, reflect the intrinsic activity of corticothalamic circuits and are associated with cognitive activities, including learning and memory, occurring during wakefulness. In this review I will present the most relevant sleep findings in schizophrenia, with particular emphasis on several recent studies that have consistently reported sleep spindle deficits in patients with schizophrenia. I will then elaborate on how these findings may contribute to a better understanding of the neurobiology of schizophrenia as well as to the development of novel pharmacological and non-pharmacological interventions to ameliorate the symptoms and cognitive impairments of schizophrenia patients.