Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin
Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin
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DOI：
10.1038/sj.ejcn.1602384
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发表时间：
2006-06-01
影响因子：
4.7
通讯作者：
Vidal, O.
中科院分区：
文献类型：
--
作者：
Gonzalez, A. Soto;Guerrero, D. Bellido;Vidal, O.
背景：代谢综合征（MS）患者发生动脉粥样硬化和心血管疾病的风险高于平均水平。炎症在动脉粥样硬化的发展中起着关键作用。高水平的急性期反应物C-反应蛋白（CRP）和铁蛋白已被报道与MS的各种成分。患者和方法：血清CRP，铁蛋白，葡萄糖，胰岛素，甘油三酯，HDL-胆固醇和总胆固醇浓度的598肥胖或超重患者进行了测定，连同相关的人体测量参数。采用HOMA法评价胰岛素抵抗。结果：中心性肥胖患者的CRP水平高于非中心性肥胖患者（5.8 vs 3.9 mg/l; P = 0.003），空腹血糖浓度≥ 110 mg/dl的患者高于空腹血糖浓度较低的患者（7.4 vs 4.1 mg/l; P = 0.01）。甘油三酯浓度≥ 150 mg/dl的患者血清铁蛋白水平高于甘油三酯浓度较低的患者（76.8 vs 40.1 ng/ml; P < 0.001），空腹血糖浓度≥ 110 mg/dl的患者血清铁蛋白水平高于甘油三酯浓度较低的患者（75.7 vs 41.7 ng/ml; P = 0.005）。符合MS标准的数量随着CRP和铁蛋白水平的增加而增加。有胰岛素抵抗的患者CRP和铁蛋白水平也高于无胰岛素抵抗的患者，CRP为7.3 vs 4.3 mg/l（P = 0.032），铁蛋白为124.5 vs 80.1 ng/ml（P < 0.001）。通过测定这些标志物来评估MS和/或胰岛素抵抗患者的亚临床慢性炎症可能有助于评估其作为针对心血管危险因素的积极干预的候选者。
Background: Patients with metabolic syndrome ( MS) have above-average risk of developing atherosclerosis and cardiovascular disease. Inflammation plays a key role in the development of atherosclerosis. High levels of the acute phase reactants C-reactive protein ( CRP) and ferritin have been reported to correlate with various components of MS.Patients and methods: The serum CRP, ferritin, glucose, insulin, triglycerides, HDL-cholesterol and total cholesterol concentrations of 598 obese or overweight patients were determined, together with relevant anthropometric parameters. Insulin resistance was evaluated by the HOMA method. MS was diagnosed using the ATP III criteria.Results: CRP levels were higher among patients with central obesity than in those without ( 5.8 vs 3.9 mg/l; P = 0.003), and higher among those with fasting plasma glucose concentrations >= 110 mg/dl than in those with lower concentrations ( 7.4 vs 4.1 mg/l; P = 0.01). Serum ferritin levels were higher among patients with triglyceride concentrations >= 150 mg/dl than in those with lower levels ( 76.8 vs 40.1 ng/ml; P < 0.001), and higher among those with fasting plasma glucose concentrations >= 110 mg/dl than in those with lower concentrations ( 75.7 vs 41.7 ng/ml; P = 0.005). The number of MS criteria that were satisfied increased with CRP and ferritin levels. Patients with insulin resistance also had higher CRP and ferritin levels than those without, 7.3 vs 4.3 mg/l for CRP ( P = 0.032) and 124.5 vs 80.1 ng/ml for ferritin ( P < 0.001).Conclusions: MS and insulin resistance are associated with elevated serum CRP and ferritin. Evaluation of subclinical chronic inflammation in patients with MS and/or insulin resistance by determination of these markers might aid in their evaluation as candidates for aggressive intervention against cardiovascular risk factors.