Quality of life following live donor renal transplantation: a single centre experience.
Quality of life following live donor renal transplantation: a single centre experience.
复制标题
活体肾移植后的生活质量：单中心经验。
作者：
Alice Shrestha;A. Shrestha;C. Basarab;W. Mckane;B. Shrestha;A. Raftery
背景
本研究的目的是检查活体供肾移植（LDRTx）受者在移植前和移植后的生活质量（QoL），并与其移植前（pre-Tx）透析状态和移植后（post-Tx）免疫抑制方案相关。
材料/方法
57名LDRTx受体和38名健康个体作为对照参与了研究。使用肾移植问卷（KTQ）和医学结局调查简表36（SF-36）问卷评估QoL。
结果
LDRTx接受者的所有SF-36维度的Tx后评分均显着高于对照组，但仍低于对照组。然而，在KTQ中，除外观（p=0.035）外的所有维度均显著增加了Tx后患者的预先移植，并且那些使用他克莫司为基础的免疫抑制药物的患者的QoL显著更好。
结论
LDRTx显著改善了QoL，这与抢先移植和他克莫司为基础的免疫抑制方案最好。
BACKGROUND
The aim of this study was to examine the quality of life (QoL) of the live donor renal transplant (LDRTx) recipients pre- and post-transplantation and correlate with their pre-transplant (pre-Tx) dialysis status and immunosuppressive regimens post-transplantation (post-Tx).
MATERIAL/METHODS
57 LDRTx recipients and 38 healthy individuals as controls participated in the study. The Kidney Transplant Questionnaire (KTQ) and the Medical Outcome Survey Short Form 36 (SF-36) questionnaires were used to assess QoL.
RESULTS
The post-Tx scores in all SF-36 dimensions were significantly higher in the LDRTx recipients, but remained lower than that of the control group. However, in the KTQ, all dimensions except Appearance (p=0.035), significantly increased post-Tx Patients transplanted pre-emptively and those on tacrolimus-based immunosuppressive drugs had significantly better QoL.
CONCLUSIONS
LDRTx significantly improved QoL, which was best with preemptive transplantation and tacrolimus-based immunosuppressive regimens.