Gender differences in autism spectrum disorders: Divergence among specific core symptoms
Gender differences in autism spectrum disorders: Divergence among specific core symptoms
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DOI：
10.1002/aur.1715
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发表时间：
2017-04-01
期刊：
影响因子：
4.7
通讯作者：
Delorme, Richard
中科院分区：
文献类型：
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作者：
Beggiato, Anita;Peyre, Hugo;Delorme, Richard
基于社区的研究一直表明，在自闭症谱系障碍(ASD)中，性别比例严重偏向男性。男性占主导地位的背后因素在很大程度上是未知的，但女孩在标准化分类诊断工具上的得分方式可能解释了女孩对自闭症认识不足的原因。尽管在几个主要的筛查测试中，对患有自闭症的男孩和女孩存在不同的常模，但自闭症诊断面谈修订版(ADI-R)的算法并未重新制定。本研究的目的是调查哪些ADI-R项目区分男性和女性，并评估它们在孤独症最终诊断中的权重。然后，我们对巴黎自闭症研究国际姐妹对(Paris)研究招募的594名先证者进行了判别分析(DA)，其中包括129名患有ASD的女性。对通过自闭症遗传资源交换(AGRE)计划招募的1716名先证者的独立样本进行了复制分析，其中包括338名患有ASD的女性。以所有ADI-R项目的原始分数为自变量，DA对78.9%的男性和72.9%的女性进行了正确分类(P
Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P