The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study
The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study
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DOI：
10.1007/s00406-011-0191-9
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发表时间：
2011-12-01
影响因子：
4.7
通讯作者：
Azimipour, Solaleh
中科院分区：
文献类型：
--
作者：
Tajalizadekhoob, Yaser;Sharifi, Farshad;Azimipour, Solaleh
由于抑郁症的社会和经济成本的上升，新的抗抑郁药物的副作用更少应该被发现。一些研究表明，欧米茄-3多不饱和脂肪酸（欧米茄-3 PUFA）和抑郁症之间存在关联。然而，这种关联在轻度至中度抑郁的老年人中还不够清楚。Kahrizak慈善基金会的66名居民参加了这项双盲、随机、安慰剂对照研究。每个参与者都是65岁，每千日元22分之一的迷你精神状态检查，老年抑郁量表-15（GDS-15）的得分范围为5到11。在6个月期间，药物组每天服用一克鱼油胶囊，其中含有300 mg二十碳五烯酸和二十二碳六烯酸。两组在教育水平、抗抑郁药物使用、酒精、烟草使用、慢性病史、年龄、体重指数（BMI）、高敏C反应蛋白（hs-CRP）、总胆固醇和基线GDS-15评分方面无显著差异。在调整胆固醇、BMI和甲状腺功能障碍史后，两组之间的GDS-15评分存在统计学显着差异。此外，与安慰剂相比，omega-3 PUFA治疗在临床上更有效地治疗抑郁症。在这项研究中，低剂量的omega-3 PUFA在治疗老年参与者的轻度至中度抑郁症方面具有一定的疗效。
Due to the rise in the social and economic costs of depression, new antidepressant medication with fewer side effects should be found. Several studies have shown that an association exists between omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and depression. However, this association has not been clear enough in the elderly with mild to moderate depression. Sixty-six inhabitants of Kahrizak Charity Foundation participated in this double-blind, randomized, placebo-controlled study. Each participant was a parts per thousand yen 65 years of age, had a Mini Mental State Exam of a parts per thousand yen 22, and had scores ranging from 5 to 11 on the Geriatric Depression Scale-15 (GDS-15). During the 6 months, the drug group was treated daily with one gram of fish oil capsule containing 300 mg of both eicosapentaenoic acid and docosahexaenoic acid. No significant differences were noted between the groups in regard to level of education, use of antidepressant drugs, alcohol, tobacco use, history of chronic diseases, age, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), total cholesterol, and GDS-15 scores at baseline. After adjusting for cholesterol, BMI, and history of thyroid dysfunctions, a statistically significant difference was seen in GDS-15 scores between both groups. Furthermore, treatment with omega-3 PUFAs was clinically more effective in treating depression in comparison with the placebo. In this study, low-dose omega-3 PUFAs had some efficacy in the treatment of mild to moderate depression in elderly participants.