Cbx4: A new guardian of p63's domain of epidermal control.
Cbx4: A new guardian of p63's domain of epidermal control.
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DOI：
10.1083/jcb.201512032
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发表时间：
2016-01-04
期刊：
影响因子：
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通讯作者：
Ezhkova E
中科院分区：
文献类型：
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作者：
Cohen I;Ezhkova E
表观遗传调节因子对发育过程中细胞谱系的选择至关重要。在这个问题上，Mardaryev et al.（2016. http：//dx.doi.org/10.1083/jcb.201506065）显示Polycomb亚基Cbx4在转录调节因子p63的下游起作用，以通过Polycomb依赖性和非依赖性SUMO E3连接酶活性维持表皮祖细胞身份和发育中的表皮增殖。
Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.