The genetic variability of HIV-1 and its implications.
The genetic variability of HIV-1 and its implications.
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HIV-1 的遗传变异及其影响。
DOI：
10.1016/s1246-7820(01)00131-8
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
M. Peeters
中科院分区：
文献类型：
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作者：
M. Peeters
本文讨论了人类免疫缺陷病毒1型（HIV-1）毒株的分类，HIV-1变异体的全球分布，HIV-1变异性对诊断测试、抗逆转录病毒药物和HIV-1疫苗开发的影响，以及不同毒株重组的影响。结论是，随着更多的HIV-1变种不可避免地在世界不同地区混合，产生新的重组病毒的可能性将增加。嵌合现象的模式将变得更加复杂，因为涉及已经重组的病毒的重组将发生。需要继续监测，以确定北美和欧洲非亚型B病毒的未来作用，并绘制世界各地新的主要亚型和循环重组形式的出现。
This paper discusses the classification of human immunodeficiency virus type 1 (HIV-1) strains, worldwide distribution of HIV-1 variants, implications of HIV-1 variability on the development of diagnostic tests, antiretroviral drugs and HIV-1 vaccines, and implications of recombination of divergent strains. It is concluded that as more HIV-1 variants inevitably intermix in different parts of the world, the likelihood of generating new recombinant viruses will increase. The pattern of mosaicism will become even more complex since recombination involving viruses that are already recombinant will occur. Continued monitoring is necessary to determine the future role of non-subtype B viruses in North America and Europe, and to chart the emergence of new predominant subytpes and circulating recombinant forms around the world.