Nrf2 mediates redox adaptations to exercise.
Nrf2 mediates redox adaptations to exercise.
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DOI：
10.1016/j.redox.2016.10.003
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发表时间：
2016-12
期刊：
影响因子：
11.4
通讯作者：
Traustadóttir T
中科院分区：
文献类型：
--
作者：
Done AJ;Traustadóttir T
本文综述了急性运动和常规运动对核因子红细胞2相关因子2（Nrf2）活性和Nrf2信号下游靶点的影响。Nrf2（在人类中由NFE2L2基因编码）是抗氧化防御的主要调节因子，是一种调节200多种细胞保护基因表达的转录因子。越来越多的证据表明，Nrf2信号在氧化应激如何介导运动的有益作用中起着关键作用。通过急性运动引起的氧化应激的发作性增加刺激Nrf2激活，并且当反复应用时，与常规运动一样，导致内源性抗氧化防御的上调和抵抗氧化应激的破坏性影响的总体能力更强。Nrf2在各种组织中响应运动而激活的证据可能是运动如何发挥其众所周知的全身效应的重要机制，这些效应不限于骨骼肌和心肌。此外，还有一些来自动物研究的新数据转化为人类。本文综述了运动对Nrf2信号通路影响的最新研究进展。急性运动通过ROS产生刺激Nrf2信号传导。Nrf2信号在ROS如何介导运动的有益作用中起着关键作用。新兴数据支持将动物研究数据转化为人类研究数据。
The primary aim of this review is to summarize the current literature on the effects of acute exercise and regular exercise on nuclear factor erythroid 2-related factor 2 (Nrf2) activity and downstream targets of Nrf2 signaling. Nrf2 (encoded in humans by the NFE2L2 gene) is the master regulator of antioxidant defenses, a transcription factor that regulates expression of more than 200 cytoprotective genes. Increasing evidence indicates that Nrf2 signaling plays a key role in how oxidative stress mediates the beneficial effects of exercise. Episodic increases in oxidative stress induced through bouts of acute exercise stimulate Nrf2 activation and when applied repeatedly, as with regular exercise, leads to upregulation of endogenous antioxidant defenses and overall greater ability to counteract the damaging effects of oxidative stress. The evidence of Nrf2 activation in response to exercise across variety of tissues may be an important mechanism of how exercise exerts its well-known systemic effects that are not limited to skeletal muscle and myocardium. Additionally there are emerging data that results from animal studies translate to humans. This review summarizes the current literature on the effects of exercise on Nrf2 signaling. Acute exercise stimulates Nrf2 signaling through ROS production. Nrf2 signaling plays a key role in how ROS mediate the beneficial effects of exercise. Emerging data support translation of data from animal studies to humans.