Hepatotoxicity of Sodium Valproate and Other Anticonvulsants in Rat Hepatocyte Cultures
Hepatotoxicity of Sodium Valproate and Other Anticonvulsants in Rat Hepatocyte Cultures
复制标题
丙戊酸钠和其他抗惊厥药对大鼠肝细胞培养物的肝毒性
DOI：
10.1111/j.1528-1157.1980.tb04323.x
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发表时间：
1980
期刊：
影响因子：
5.6
通讯作者：
K. G. Tolman
中科院分区：
文献类型：
--
作者：
E. Kingsley;R. Tweedale;K. G. Tolman
摘要：最近证明丙戊酸与人类肝脏疾病有关。大鼠肝细胞培养物用于测试丙戊酸和其他几种抗惊厥药的肝毒性。丙戊酸在浓度范围为 10 至 320 μg/ml（治疗浓度为 50-100 μg/ml）时显示出与剂量相关的肝毒性。苯巴比妥、苯妥英、扑米酮和氯硝西泮未证实有肝毒性。结论是丙戊酸是一种剂量相关的肝毒素。
Summary: Valproic acid has recently been shown to be associated with liver disease in man. Rat hepatocyte cultures were used to test the hepatotoxicity of valproic acid and several other anticonvulsants. Dose‐related hepatotoxicity was demonstrated for valproic acid at concentrations ranging from 10 to 320 /ig/ml, therapeutic concentrations being 50–100 μg/ml. Hepatotoxicity could not be demonstrated for phenobarbital, phenytoin, primidone, and clonazepam. It is concluded that valproic acid is a dose‐related hepatotoxin.