Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
复制标题
DOI：
10.1101/gad.1302105
复制
发表时间：
2005-05-01
影响因子：
10.5
通讯作者：
Heintz, N
中科院分区：
文献类型：
--
作者：
Anthony, TE;Mason, HA;Heintz, N
放射状胶质细胞在中枢神经系统发育过程中既作为神经祖细胞又作为支持神经元迁移的支架发挥作用。为了阐明参与这些功能的途径，我们在体内绘制了放射状神经胶质基因Blbp的启动子。我们在这里表明，Notch效应CBF1的结合位点是放射状神经胶质细胞中所有Blbp转录所必需的，并且在缺乏Notch1和Notch3受体的小鼠的前脑中，BLBP表达显著降低。这些结果确定Blbp作为第一个主要的CNS特异性Notch靶基因，并表明它介导放射状神经胶质细胞中Notch信号传导的某些方面。
Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene. We show here that a binding site for the Notch effector CBF1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch1 and Notch3 receptors. These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia.