β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
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DOI：
10.2337/diabetes.52.1.102
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发表时间：
2003-01-01
期刊：
影响因子：
7.7
通讯作者：
Butler, PC
中科院分区：
文献类型：
--
作者：
Butler, AE;Janson, J;Butler, PC
2型糖尿病的特征是胰岛素分泌受损。一些但不是所有的研究表明，β细胞质量的减少对此有贡献。我们检查了12 4例身体的胰腺组织：91例肥胖患者(体重指数和血糖；27 kg/m(2)；41例2型糖尿病，15例空腹血糖受损，35例非糖尿病受试者)和33例消瘦患者(13111
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in beta-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m(2); 41 with type 2 diabetes, 15 with impaired fasting glucose [IFG], and 35 nondiabetic subjects) and 33 lean cases (13111