The impact of obesity on hormonal parameters in hirsute and nonhirsute women
The impact of obesity on hormonal parameters in hirsute and nonhirsute women
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DOI：
10.1016/s0026-0495(96)90202-4
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发表时间：
1996-01-01
影响因子：
9.8
通讯作者：
Marugo, M
中科院分区：
文献类型：
--
作者：
Bernasconi, D;DelMonte, P;Marugo, M
肥胖对多毛和无多毛妇女性激素结合球蛋白（SHBG）和雄激素浓度的影响已被评估。该研究在226名多毛妇女（88名肥胖和138名非肥胖）中进行，这些多毛妇女被归类为受多囊卵巢综合征（PCOS）或特发性多毛症（IH）影响，并在100名非多毛对照妇女（[C] 60名瘦和40名肥胖）中进行。在月经周期的第一周，通过放射免疫法（RIA）测定SHBG、游离睾酮（fT）、雄烯二酮（A）、雌二醇（E2）、硫酸脱氢表雄酮（DHEAS）和促性腺激素水平。在PCOS、IH和C女性中观察到SHBG与体重指数（BMI）之间存在显著负相关。在肥胖女性中，无论是PCOS、IH还是C-fT水平均显著高于非肥胖女性，相反，SHBG水平均低于非肥胖女性。各组SHBG与fT呈负相关。上半身肥胖与较低的SHBG和较高的fT水平比下半身肥胖。总之，肥胖，特别是上半身肥胖，与无多毛和多毛妇女的SHBG降低和fT增加有关。版权所有（C）1996由W.B.桑德斯公司
The influence of obesity on sex hormone-binding globulin (SHBG) and androgen concentrations in hirsute and nonhirsute women has been evaluated. The study was performed in 226 hirsute women (88 obese and 138 non-obese) classified as being affected by polycystic ovarian syndrome (PCOS) or by idiopathic hirsutism (IH) and in 100 nonhirsute control woman ([C] 60 lean and 40 obese). SHBG, free testosterone (fT), androstenedione (A), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), and gonadotropin levels were measured during the first week of the menstrual cycle by radioimmunoassay (RIA). A significant negative correlation between SHBG and body mass index (BMI) was observed in PCOS, IH, and C women. In obese women-whether PCOS, IH, or C-fT levels were significantly higher and, conversely, SHBG levels were lower than in non-obese women. A negative correlation between SHBG and fT was evidenced in each group. Upper body obesity was associated with lower SHBG and higher fT levels than lower-body obesity. In conclusion, obesity, particularly upper-body obesity, is associated with a reduction in SHBG and an increase in fT in both nonhirsute and hirsute women. Copyright (C) 1996 by W.B. Saunders Company