Angiogenesis in corneal diseases: Histopathologic evaluation of 254 human corneal buttons with neovascularization
Angiogenesis in corneal diseases: Histopathologic evaluation of 254 human corneal buttons with neovascularization
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DOI：
10.1097/00003226-199811000-00008
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发表时间：
1998-11-01
期刊：
影响因子：
2.8
通讯作者：
Naumann, GOH
中科院分区：
文献类型：
--
作者：
Cursiefen, C;Kuchle, M;Naumann, GOH
目的。角膜疾病中的血管生成可能需要角膜移植并引起移植物排斥。本研究的目的是找出角膜移植术中切除的人角膜中血管生成的组织病理学发生率，建立与血管生成最常见的组织病理学诊断，并评估新角膜血管的解剖位置。方法。 1992 年至 1996 年间，角膜移植术后的角膜扣片 (2,557 个) 被送往我们的眼病理实验室进行分析。其中，本研究随机检索并评估了其中 1,278 个全层角膜扣片和板层角膜扣片。结果。通过角膜移植术获得的 1,278 个人类角膜纽扣中，有 254 个（19.9%）显示出血管生成。相关的组织病理学诊断为 (a) 角膜炎后疤痕形成 (109, 45.4%)； (b) 移植物排斥和功能不全（73 例，30.4%）； (c) 急性坏死性溃疡性角膜炎（30，12.5%）； (d) 机械或化学损伤后留下疤痕 (28, 11.7%)。组织病理学上，新生血管通常与角膜水肿或炎症细胞或两者相关（76%）。新血管最常见的位置是角膜基质的上三分之一和中三分之一。只有 11% 的新血管仅位于深层基质层。结论。血管生成是导致角膜移植的角膜疾病的常见组织病理学特征，在 19.9% 的切除人角膜扣中发现了血管生成。全身或局部抗血管生成治疗可以减少角膜移植和再移植的需要。
Purpose. Angiogenesis in corneal diseases can necessitate corneal transplantation and induce graft rejection. The aim of this study was to find out the histopathologic prevalence of angiogenesis in human corneas removed during keratoplasty, to establish the histopathologic diagnoses most commonly associated with angiogenesis, and to evaluate the anatomic location of new corneal vessels. Methods. Corneal buttons (2,557) after keratoplasty were sent to and analyzed in our ophthalmopathology laboratory between 1992 and 1996. Of these, 1,278 full-thickness and lamellar corneal buttons were randomly retrieved and evaluated in this study. Results. Of 1,278 human corneal buttons obtained by keratoplasty, 254 (19.9%) showed angiogenesis. Associated histopathologic diagnoses were (a) scarring after keratitis (109, 45.4%); (b) graft rejection and insufficiency (73, 30.4%); (c) acute necrotizing ulcerative keratitis (30, 12.5%); and (d) scarring after mechanical or chemical injuries (28, 11.7%). Histopathologically, new vessels were usually associated with corneal edema or inflammatory cells or both (76%). The most common locations of new vessels were the upper and middle third of the corneal stroma. Only 11% of new vessels were located solely in the deep stromal layers. Conclusion. Angiogenesis is a common histopathologic feature of corneal diseases leading to corneal transplantation and was found in 19.9% of excised human corneal buttons. Systemic or topical antiangiogenic therapy could reduce the need for corneal transplantation and retransplantation.