Resistance training, sarcopenia, and the mitochondrial theory of aging
Resistance training, sarcopenia, and the mitochondrial theory of aging
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DOI：
10.1139/h07-141
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Parise, Gianni
中科院分区：
文献类型：
--
作者：
Johnston, Adam P. W.;De Lisio, Michael;Parise, Gianni
骨骼肌衰老与肌肉质量、力量、功能和生活质量的显着损失有关。此外，老龄化和与年龄相关的疾病的医疗保健费用正在增加，并且随着我们人口中越来越多的人达到退休年龄或超过退休年龄，这种费用将继续增加。线粒体衰老理论被认为是对衰老过程的主要解释，并描述了导致细胞衰老的途径，包括电子传递链缺陷、活性氧产生以及线粒体 DNA 缺失和突变的积累。同样很明显的是，定期的抗阻运动是骨骼肌衰老的有效对策。在这篇综述中，我们讨论了与年龄相关的肌肉减少症、衰老的线粒体理论，以及抗阻运动如何直接影响线粒体理论的关键组成部分。从讨论的数据中可以清楚地看出，定期的阻力训练可以有效地干扰导致衰老进程的过程，因为它与线粒体理论有关。
Skeletal muscle aging is associated with a significant loss of muscle mass, strength, function, and quality of life. In addition, the healthcare cost of aging and age-related disease is growing, and will continue to grow as a larger proportion of our population reaches retirement age and beyond. The mitochondrial theory of aging has been identified as a leading explanation of the aging process and describes a path leading to cellular senescence that includes electron transport chain deficiency, reactive oxygen species production, and the accumulation of mitochondrial DNA deletions and mutations. It is also quite clear that regular resistance exercise is a potent and effective countermeasure for skeletal muscle aging. In this review, we discuss age-related sarcopenia, the mitochondrial theory of aging, and how resistance exercise may directly affect key components of the mitochondrial theory. It is clear from the data discussed that regular resistance training can effectively disturb processes that contribute to the progression of aging as it pertains to the mitochondrial theory.