Design and Implementation of an Organic to Analytical CURE Sequence
Design and Implementation of an Organic to Analytical CURE Sequence
复制标题
DOI：
10.1021/acs.jchemed.1c00129
复制
发表时间：
2021-06-16
影响因子：
3
通讯作者：
Walker, Joi P.
中科院分区：
文献类型：
--
作者：
Allen, William E.;Hosbein, Kathryn N.;Walker, Joi P.
本文介绍了一种基于课程的本科化学研究经验（CURE）序列的设计和实现，该序列将低年级的有机化学课程与高年级的分析化学课程联系起来。学生研究的重点是使用海藻糖衍生物来保存血液，以模仿缓步动物，一种微小的极端微生物，它产生糖分子以在干燥和冷冻中生存。学生们在有机CURE中创建了一个修饰糖分子库，然后在分析CURE中评估这些分子在膜内的行为。CURE序列在三个学生队列中运行，这些学生队列被选中以匹配课程中所有学生的人口统计数据。本文详细介绍了学生选拔过程、课程设计、教师实施和修订。调查结果证明了CURE的保真度。我们还描述了为适应COVID-19限制而调整研究课程的情况。
This paper describes the design and implementation of a course-based undergraduate research experience (CURE) sequence in chemistry that links a lower-division, organic chemistry course to an upper-division, analytical chemistry course. The focus of student research is on blood preservation using trehalose derivatives in order to mimic the tardigrade, a microscopic extremophile, which produces sugar molecules to survive desiccation and freezing. Students created a library of modified sugar molecules in the organic CURE and then evaluated the behavior of those molecules within membranes in the analytical CURE. The CURE sequence has been run with three student cohorts which were selected to match the demographics of all students in the course. This article details the student selection process, the course design, the faculty implementation, and revisions. Fidelity of the CURE is demonstrated with survey results. We also describe adaptation of the research courses to accommodate the COVID-19 restrictions.