Adaptive coding of reward value by dopamine neurons
Adaptive coding of reward value by dopamine neurons
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DOI：
10.1126/science.1105370
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发表时间：
2005-03-11
期刊：
影响因子：
56.9
通讯作者：
Schultz, W
中科院分区：
文献类型：
--
作者：
Tobler, PN;Fiorillo, CD;Schultz, W
对动物来说，尽可能准确地估计奖励的价值是很重要的。因为潜在奖励价值的数量非常大，所以有必要分配大脑有限的资源来进行歧视！在更可能的奖励结果中更好，但代价是不太可能的结果。我们发现，中脑多巴胺神经元对奖赏预测刺激提供的信息迅速适应。反应相对于预期奖励值移动，而收益调整为奖励值的方差。通过这种方式，多巴胺神经元在大范围的奖赏价值范围内保持其奖赏敏感性。
It is important for animals to estimate the value of rewards as accurately as, possible. Because the number of potential reward values is very large, it is necessary that the brain's limited resources be allocated so as to discriminate! better among more likely reward outcomes at the expense of less likely outcomes. We found that midbrain dopamine neurons rapidly adapted to the information provided by reward-predicting stimuli. Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values.