Role of the bronchial circulation in ischemia-reperfusion lung injury.
Role of the bronchial circulation in ischemia-reperfusion lung injury.
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支气管循环在缺血再灌注肺损伤中的作用。
DOI：
10.1152/jappl.1994.76.1.259
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Wagner,EM
中科院分区：
文献类型：
--
作者：
Pearse,DB;Wagner,EM
支气管动脉（BA）灌注可通过支气管-肺吻合口或肺血管-血管流维持肺血管完整性，促进支气管周围水肿的清除或限制水肿的形成，从而改善肺动脉（PA）缺血-再灌注（IR）损伤。本研究的目的是确定BA灌注对离体绵羊肺IR损伤的影响。在12只肺（ba++）中，BA在PA缺血30min和再灌注180min时灌注。12只肺（BA-+） BA灌注开始于PA再灌注，15只肺（BA-） BA未灌注。180min后，BA++和B-+肺（4.70 +/- 0.16和4.57 +/- 0.18 g/g无血干肺（bfdl））血管外肺水少于BA-肺（5.23 +/- 0.19 g/g bfdl） （P < 0.05）。ba++和BA-+的白蛋白反射系数分别为0.57 +/- 0.06和0.75 +/- 0.03，高于BA-肺（0.44 +/- 0.04）（P < 0.05）。BA++和BA-+肺的过滤系数（0.016 +/- 0.006和0.015 +/- 0.006 g.min-1 × mmHg-1 × kg-1）与BA-肺的过滤系数（0.025 +/- 0.006 g.min-1 × mmHg-1 × kg-1）无显著差异。这些结果提示BA灌注通过减弱IR损伤引起的肺血管通透性增加来减少再灌注水肿。此外，BA-+肺的结果表明，保护作用是由PA血管的BA灌注介导的，而不是由支气管肺吻合口血流介导的，与PA血流相比微不足道。
Bronchial arterial (BA) perfusion could modify pulmonary arterial (PA) ischemia-reperfusion (IR) injury by promoting clearance of peribronchial edema or limiting edema formation through maintenance of pulmonary vessel integrity via bronchopulmonary anastomotic or pulmonary vasa vasorum flow. The purpose of this study was to determine the effect of BA perfusion on IR injury in isolated sheep lungs. In 12 lungs (BA++) the BA was perfused throughout 30 min of PA ischemia and 180 min of reperfusion. In 12 lungs (BA-+) BA perfusion was begun with PA reperfusion, and in 15 lungs (BA--) the BA was never perfused. After 180 min, extravascular lung water was less (P < 0.05) in BA++ and B-+ lungs [4.70 +/- 0.16 and 4.57 +/- 0.18 g/g blood-free dry lung (bfdl)] than in BA-- lungs (5.23 +/- 0.19 g/g bfdl). The reflection coefficient for albumin was greater (P < 0.05) in BA++ and BA-+ (0.57 +/- 0.06 and 0.75 +/- 0.03) than in BA-- lungs (0.44 +/- 0.04). The filtration coefficient in BA++ and BA-+ lungs (0.016 +/- 0.006 and 0.015 +/- 0.006 g.min-1 x mmHg-1 x kg-1) was not different from that in BA-- lungs (0.025 +/- 0.006 g.min-1 x mmHg-1 x kg-1). These results suggest that BA perfusion decreased reperfusion edema by attenuating the increase in pulmonary vascular permeability caused by IR injury. Moreover the result in BA-+ lungs suggests that the protective effect was mediated by BA perfusion of PA vasa vasorum rather than bronchopulmonary anastomotic flow, which was trivial compared with PA blood flow.