Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients
Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients
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DOI：
10.1001/jama.281.4.354
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发表时间：
1999-01-27
影响因子：
120.7
通讯作者：
Steinberg, KP
中科院分区：
文献类型：
--
作者：
Davidson, TA;Caldwell, ES;Steinberg, KP
急性呼吸窘迫（ARDS）患者的健康相关生活质量（HRQL）降低，但HRQL的下降是由ARDS还是患者疾病或损伤的其他方面引起的尚不清楚。目的探讨急性呼吸窘迫综合征（ARDS）幸存者与未患ARDS的对照者的HRQL是否存在差异。设计前瞻性、匹配、平行队列研究。设置有411张床位的市级和区级一级创伤中心。研究对象：1994年1月1日至1996年7月30日收治的伴有败血症和创伤性ARDS临床危险因素的73对ARDS幸存者和严重程度匹配的对照者，主要观察指标：ARDS幸存者和对照者的HRQL，分别采用通用HRQL仪器和肺部疾病特异性HRQL仪器（医学结局研究36-Item Short Form Health Survey，标准表格[SF-36]和圣乔治呼吸问卷[SGRQ]）进行评估。结果与对照组相比，ARDS幸存者（n = 73）在8个SF-36域中的7个和3个SGRQ域中的3个HRQL评分有临床意义和统计学意义的降低（P < 0.05）
Context Health-related quality of life (HRQL) is reduced in patients who survive acute respiratory distress (ARDS), but whether this decline in HRQL is caused by ARDS or other aspects of the patient's illness or injury is unknown.Objective To determine if there are differences in the HRQL of ARDS survivors and comparably ill or injured controls without ARDS.Design Prospective, matched, parallel cohort study.Setting A 411-bed municipal medical and regional level I trauma center.Patients Seventy-three pairs of ARDS survivors and severity-matched controls with the clinical risk factors for ARDS of sepsis and trauma admitted between January 1, 1994, and July 30, 1996,Main Outcome Measures The HRQL of ARDS survivors and controls, assessed by generic and pulmonary disease-specific HRQL instruments (Medical Outcomes Study 36-Item Short Form Health Survey, Standard Form [SF-36] and St George's Respiratory Questionnaire [SGRQ], respectively).Results Clinically meaningful and statistically significant reductions in HRQL scores of ARDS survivors (n = 73) were seen in 7 of 8 SF-36 domains and 3 of 3 SGRQ domains compared with matched controls (P