Opposing effects of L-NAME on capillary filtration rate in the presence or absence of neutrophils.
Opposing effects of L-NAME on capillary filtration rate in the presence or absence of neutrophils.
复制标题
在存在或不存在中性粒细胞的情况下，L-NAME 对毛细血管滤过率产生相反的影响。
DOI：
10.1152/ajpgi.1997.273.6.g1320
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Harris,NR
中科院分区：
文献类型：
--
作者：
Harris,NR
Fluid filtration rate (Jv/S) from rat mesenteric capillaries was measured using a modified Landis technique before and after superfusion with 100 μMNG-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor. Three groups were studied:1) control rats,2) rats injected with antineutrophil serum (ANS), and3) rats injected with a monoclonal antibody (CL26) against the leukocyte adhesion molecule CD18. The relative increase inJv/S(l-NAME/baseline) in control rats averaged 1.66 ± 0.32 (n= 11), which was significantly higher (P< 0.05) than in ANS (0.51 ± 0.12;n= 5)- and CL26 (0.45 ± 0.16;n= 6)-injected rats exposed tol-NAME. Thel-NAME-induced changes inJv/Sin each group were due to altered permeability rather than altered pressure gradients, as determined by measurements of arteriolar hydrostatic pressure (using a servo-null apparatus) and estimates of intravascular oncotic pressure (using plasma protein concentration). These findings indicate that nitric oxide synthase inhibition increases the permeability of mesenteric capillaries to water, a response that is dependent on neutrophil adhesion.
