Alternans and the onset of ventricular fibrillation.
Alternans and the onset of ventricular fibrillation.
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DOI：
10.1103/physreve.62.4043
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发表时间：
2000-09
期刊：
影响因子：
--
通讯作者：
H. Hastings;F. Fenton;S. Evans;O. Hotomaroglu;J. Geetha;K. Gittelson;J. Nilson;A. Garfinkel
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文献类型：
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作者：
H. Hastings;F. Fenton;S. Evans;O. Hotomaroglu;J. Geetha;K. Gittelson;J. Nilson;A. Garfinkel
心室颤动（VF）仍然是工业化世界的一个主要死亡原因。交替（心脏电活动的一种周期加倍的分叉）最近被认为与室性心动过速（VT）向VF（一种更时空混乱的电活动）的进展有因果关系。在本文中，我们展示了交替和室性心律失常如何通过多种特定的动力学途径退化为混沌，这在很大程度上与室性心律失常动力学的空间成分有关，解释了许多最近提出的抗心律失常药物的失败。确定室性心律失常发病的动力学机制将有助于设计未来的实验，从而开发出更有效的抗心律失常药物。
Ventricular fibrillation (VF) remains a major cause of death in the industrialized world. Alternans (a period-doubling bifurcation of cardiac electrical activity) have recently been causally linked to the progression from ventricular tachycardia (VT) to VF, a more spatiotemporally disorganized electrical activity. In this paper, we show how alternans and thus VT degenerate to chaos via multiple, specific dynamical routes, largely associated with spatial components of VF dynamics, explaining failures of many recently proposed antiarrhythmic drugs. Identification of dynamical mechanisms for the onset of VF should lead to the design of future experiments and consequently to more effective antiarrhythmic drugs.