Topical photodynamic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia
Topical photodynamic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia
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DOI：
10.1111/j.1600-0714.2010.00935.x
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发表时间：
2010-09-01
影响因子：
3.3
通讯作者：
Chiang, Chun-Pin
中科院分区：
文献类型：
--
作者：
Lin, Hung-Pin;Chen, Hsin-Ming;Chiang, Chun-Pin
背景：口腔疣状增生（Oral verrucous hyperplasia，OVH）和口腔红斑白斑（oral erythroleukoplakia，OEL）是两种具有较高恶变潜能的口腔癌前病变。最好的癌症预防策略之一是使用保守有效的治疗方式来消除口腔癌前病变，以阻止其进一步恶性转化。我们以前的研究表明，局部5-氨基乙酰丙酸介导的光动力疗法，方法：由于激光机是PDT诊所中比LED设备更流行的光源，因此在本研究中，40个OVH和40个OEL病变每周用相同的PDT方案治疗一次，但使用635-nm激光，以评估这种激光介导的局部ALA-PDT是否对OVH和OEL病变也有效。我们发现，所有40个OVH病变表现出完全反应（CR）后，平均3.6 PDT治疗。在40个OEL病灶中，38个在平均3.4次PDT治疗后显示CR，2个显示部分缓解（PR）。较好的PDT结果与OVH和OEL病变的较小尺寸，粉红色到红色，上皮异型增生，或较薄的表面角蛋白层显着相关。结论：这项研究表明，激光介导的局部ALA-PDT对OVH和OEL病变也是非常有效的。因此，我们建议使用LED或激光的局部ALA-PDT可以作为OVH和OEL病变的一线治疗选择。
Background:Oral verrucous hyperplasia (OVH) and oral erythroleukoplakia (OEL) are two oral precancerous lesions with relatively high malignant transformation potential. One of the best cancer prevention strategies is to use a conservative and effective treatment modality to eliminate oral precancers to stop their further malignant transformation. Our previous studies have shown that the topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) using the 635-nm light-emitting diode (LED) light is very effective for OVH and OEL lesions.Methods:Because the laser machine is a more-popular light source than the LED device in PDT clinics, in this study 40 OVH and 40 OEL lesions were treated once a week with the same PDT protocol but using the 635-nm laser light to evaluate whether this laser light-mediated topical ALA-PDT was also effective for OVH and OEL lesions.Results:We found that all the 40 OVH lesions exhibited complete response (CR) after an average of 3.6 PDT treatments. Of the 40 OEL lesions, 38 showed CR after an average of 3.4 PDT treatments and two showed partial response (PR). Better PDT outcomes were significantly associated with OVH and OEL lesions with the smaller size, pink to red color, epithelial dysplasia, or thinner surface keratin layer.Conclusion:This study indicates that the laser light-mediated topical ALA-PDT is also very effective for OVH and OEL lesions. Therefore, we suggest that topical ALA-PDT using either the LED or laser light may serve as the first-line treatment of choice for OVH and OEL lesions.