Small non-coding RNAs and genomic imprinting
Small non-coding RNAs and genomic imprinting
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DOI：
10.1159/000090820
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发表时间：
2006-01-01
影响因子：
1.7
通讯作者：
Cavaille, J.
中科院分区：
文献类型：
--
作者：
Royo, H.;Bortolin, M. -L.;Cavaille, J.
实验和计算机辅助方法已经导致鉴定了数百个印迹小RNA基因，主要聚集在两个染色体结构域（人15 q11-> q13和14 q32基因座）中。这些基因仅在胎盘哺乳动物中检测到，属于C/D RNA和microRNA基因家族。这些是分别参与RNA引导的转录后RNA修饰和RNA介导的基因沉默的小的非编码RNA。在这里，我们讨论了它们的潜在功能，并报告了新的小RNA基因内（或附近）已知的印记染色体结构域的识别。版权所有（c）2006 S. Karger AG，巴塞尔。
Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q1 1 -> q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications and RNA-mediated gene silencing, respectively. Here, we discuss their potential functions and report the identification of novel small RNA genes lying within (or nearby) known imprinted chromosomal domains. Copyright (c) 2006 S. Karger AG, Basel.