The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Light, electron microscopic, tissue, and organ culture observations
The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Light, electron microscopic, tissue, and organ culture observations
复制标题
分化型髓母细胞瘤与去分化弥漫性小脑星形细胞瘤的关系。
作者：
L. J. Rubinstein;M. Herman;John W. Hanberv
本文报道了一例罕见的14岁女孩小脑和脑干胶质瘤的光镜、电子显微镜和组织器官培养观察，发现弥漫浸润性星形细胞瘤和局灶性髓母细胞瘤。虽然体外研究显示该肿瘤从原始的髓母细胞瘤细胞逐渐分化为富含胶质细丝的星形胶质细胞，但该肿瘤作为一个整体被解释为弥漫性小脑星形细胞瘤去分化为髓母细胞瘤的例外情况。给出了这种解释的原因，并根据关于髓母细胞瘤分化能力的有争议的观点讨论了该病例。
Light, electron microscopic, and tissue and organ culture observations are reported on an unusual example of cerebellar and brainstem glioma in a 14‐year‐old girl, which showed the concomitant picture of diffusely infiltrating astrocytoma and focal medulloblastoma. Although the in vitro studies on this neoplasm demonstrated progressive differentiation from primitive medulloblastoma cells into astrocytes rich in glial filaments, the tumor as a whole was interpreted as an exceptional case of diffuse cerebellar astrocytoma dedifferentiating into medulloblastoma. The reasons for this interpretation are given, and the case is discussed in the light of the controversial views regarding the differentiating capabilities of the medulloblastoma.