Coexistence of neuroactive substances as revealed by immunohistochemistry with monoclonal antibodies
Coexistence of neuroactive substances as revealed by immunohistochemistry with monoclonal antibodies
复制标题
免疫组织化学与单克隆抗体揭示神经活性物质的共存
DOI：
10.1007/978-1-349-06239-3_7
复制
发表时间：
1982
期刊：
影响因子：
3.3
通讯作者：
A. Cuello
中科院分区：
文献类型：
--
作者：
J. Priestley;A. Cuello
神经活性物质可能在神经元中共存的想法并不新鲜，实际上可能可以追溯到Burn和Rand（1959）关于某些节后交感神经中乙酰胆碱（ACh）和去甲肾上腺素（NA）存在的最初假设。虽然最初提出的这一假设尚未得到证实，但已经证明自主神经元可以产生乙酰胆碱或去甲肾上腺素（回顾，见Patterson， 1978）。这些早期的想法及其对当前共存概念的影响已经被许多作者（Burnstock, 1976；另见Burnstock， Jaim Etcheverry和Zieher，以及Osborne，第6、8和9章）进行了回顾。然而，直到最近，一个神经元可能含有不止一种神经活性物质的观点才被普遍接受，这在很大程度上是由于神经系统中多肽的发现以及免疫组织化学技术对其定位的应用（有关综述，见Cuello, 1978; Emson, 1979; Hokfelt et al., 1980a）。
The idea that neuroactive substances may coexist in neurones is not new and indeed probably goes back as far as the original hypothesis of Burn and Rand (1959) concerning the presence of acetylcholine (ACh) along with noradrenaline (NA) in certain postganglionic sympathetic nerves. Although this hypothesis as originally proposed has not been confirmed it has been shown that autonomic neurones can produce alternatively acetylcholine or noradrenaline (for review, see Patterson, 1978). These early ideas and their implications for present concepts of coexistence have been reviewed by a number of authors (Burnstock, 1976; see also Burnstock, Jaim Etcheverry and Zieher, and Osborne, chapters 6, 8 and 9). Yet it is only recently that the idea that a neurone may contain more than one neuroactive substance has found general acceptance, and this has been largely due to the discovery of peptides in the nervous system and to the application of immunohistochemical techniques for their localisation (for reviews, see Cuello, 1978; Emson 1979; Hokfelt et al., 1980a).