A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested
A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested
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DOI：
10.1007/s10787-017-0311-x
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发表时间：
2017-04-01
影响因子：
5.8
通讯作者：
Vitetta, Luis
中科院分区：
文献类型：
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作者：
Bambling, Matthew;Edwards, Sophie C.;Vitetta, Luis
大约有三分之一的抑郁症患者对治疗反应不佳，随着时间的推移可能会对治疗产生抗药性。肠道生态失调与抑郁症、全身性炎症、迷走神经和肠神经损伤有关。我们报告了一项后续的试点研究（n = 12）与组合益生菌/乳清酸镁制剂佐剂与SSRIs治疗难治性抑郁症。在为期8周的干预结束时，该组的抑郁评分和生活质量的平均变化在临床上显着改善（p < 0.001），除4名参与者外，所有参与者都受益。提示肠道抗炎反应。在16周的随访中，尽管仍在服用SSRI药物，但该组在停止测试干预后复发。
Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0.001) with all but 4 participants experiencing a benefit. An intestinal anti-inflammatory response was suggested. At 16-weeks follow-up while still on SSRI medications, the group had relapsed after cessation of the test intervention.